脂肪因子与动脉粥样硬化之间的研究进展

Advances in Research of Adipokines and Atherosclerosis

动脉粥样硬化是多种疾病的病因,导致全身性病变,发病率、病死率居高不下,而脂肪因子已被证实作为危险的独立影响因子。脂肪组织通过产生脂联素、瘦素、内脂素、Ⅰ型纤溶酶原激活物抑制因子、肾素-血管紧张素系统、丝氨酸蛋白酶抑制剂、趋化素等脂肪因子影响着多项生理过程。动脉硬化病变与脂肪因子之间存在密切关联;但目前还没有明确的认识脂肪因子与动脉粥样硬化之间的关系,现对脂肪因子与动脉粥样硬化的关系研究进行综述。

Atherosclerosis is the cause of many diseases,leading to systemic disease,and the morbidity and mortality rate remains high,while the adipokines have been identified as an independent risk factor.Adipose tissue affects a large number of physiological processes through the production of adiponectin,leptin,visfatin,Pai-1,RAS,vaspin,chemerin and other adipokines.Atherosclerotic lesions and adipokines are closely related.However,there is no clear understanding of the relationship between adipokines and atherosclerosis.Therefore,this article reviews the relationship between adipokines and atherosclerosis.