网织红细胞血红蛋白含量测定诊断不同人群缺铁性贫血临床分析

Determination of Hemoglobin Content of Reticulocytes in Diagnosis of Iron Deficiency Anemia in Different Populations

目的:分析网织红细胞血红蛋白含量(Ret-He)测定诊断不同人群缺铁性贫血(IDA)的临床价值。方法:选择30例IDA成人、48例IDA儿童及35例IDA孕妇,使用全自动血细胞分析仪测定红细胞相关参数(RBC、MCH、Hb、MCV)及Ret-He,并与同期健康成人、儿童、孕妇进行比较。结果:IDA成人、IDA儿童及IDA孕妇的RBC、MCH、Hb、MCV及Ret-He均明显低于相应的健康成人、儿童、孕妇(P<0.05)。Ret-He诊断成人IDA的灵敏度和特异度分别为90.0%、83.3%,诊断儿童IDA分别为93.8%、87.5%,诊断孕妇IDA分别为91.4%、85.7%。结论:Ret-He对成人、儿童、孕妇IDA的诊断均显示出较高的灵敏度和特异度,优于传统血液学参数,临床应用价值高。

Objective： To investigate the application of hemoglobin （Hb） content of reticulocytes （Ret-He） in the diagnosis of iron deficiency anemia （IDA） in different populations. Methods： A total of 30 cases of adults with IDA, 48 cases of children with IDA and 35 cases of pregnant women with IDA were selected as subjects, and the same number of adults, children and pregnant women were selected as controls. Red blood cells （RBC）, mean corpuscular hemoglobin （MCH）, Hb, mean corpuscular volume （MCV） and Ret-He were determined by the automatic blood cell analyzer. Results： The RBC, MCH, Hh, MCV and Ret-He of IDA in adults, children and pregnant women were significantly lower than those in healthy adults, children and pregnant women （P〈 0.05） . The sensitivity and specificity of Ret-He in the diagnosis of IDA were respectively 90% and 83.3% in adults, 93.8% and 87.5% in children, and 91.4% and 85.7% in pregnant women, which were better than those of RBC, MCH, Hb and MCV. Conclusion： The Ret-Hc measurement show a high sensitivity and specificity for diagnosis of IDA in adults, children and pregnant women, which is superior to traditional hematological parameters and deserves clinical application.