阿尔茨海默病的遗传学研究进展

Advances in genetics of Alzheimer's disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种常见的中枢神经性退行性疾病。普遍认为AD的发生是遗传、环境、代谢等多种因素共同作用的结果。自20世纪末AD的研究进入到分子遗传学和基因组学的水平以来,陆续发现了一些AD的易感基因。本文将就2016年至今AD易感基因(ABCA7,APOE,CLU,ESR2,CR1,INPP5D,BIN1,CD2AP,PICALM,SLC242A,APP,MTHFR,PSEN1,PSEN2,SORL1,PTK2B,TOMM40,PTGS2,ZCWPW1,FERMT2)的遗传学研究进展作一综述。

Alzheimer＇s disease （AD） is a common central neurodegenerative disease. It is generally believed that the occurrence of AD is the result of the interaction among genetic, environmental, metabolic and other factors. The AD research reach level of molecular genetics and genomics since the end of the 20th century have gradually revealed some genes implicated in AD. Here we review the AD risk genes （ ABCA7, APOE, CLU, ESR2, CR1, INPP5D, BIN1, CD2AP, PICALM, SLC242A, APP, MTHFR, PSEN1, PSEN2, SORL1 ,PTK2B ,TOMMdO ,PTGS2 ,ZCWPW1 ,FERMT2 ） for AD since 2016.