帕罗西汀与艾司西酞普兰治疗老年抑郁症的疗效及安全性

Effect of paroxetine and escitalopram on clinical efficacy and adverse reactions in elderly patients with depression

目的探究帕罗西汀与艾司西酞普兰治疗老年抑郁症的临床疗效及不良反应的影响。方法选取我院2014年3月至2016年3月期间收治的82例老年抑郁症患者作为研究对象,将其随机分为两组,帕罗西汀组和艾司西酞普兰组,每组41例患者。两组患者分别给予艾司西酞普兰和盐酸帕罗西汀口服治疗,治疗前均进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分,用症状量表(TESS)评定药物安全性,之后在治疗2周、4周、8周时再次进行评分,比较评分结果。结果治疗前两组患者HAMD与HAMA评分比较,差异无统计学意义(P>0.05);治疗后同组间比较,评分显著呈阶梯式逐渐减低;两组间比较,治疗前、治疗2周时无显著差异;治疗4周之后,艾司西酞普兰组效果优于帕罗西汀组(P<0.05)。两组患者GDS评分比较,治疗前无统计学意义(P>0.05);治疗后同组间比较,评分显著呈阶梯式逐渐减低;两组间比较,治疗2周之后直至治疗6周,艾司西酞普兰组效果优于帕罗西汀组(P<0.05);治疗后8周,评分无显著差异(P>0.05)。结论老年抑郁症治疗中帕罗西汀与艾司西酞普兰均有显著疗效,艾司西酞普兰见效更快,安全性更高。

Objectives To investigate the effect of paroxetine and escitalopram on clinical efficacy and adverse reactions in elderly patients with depression. Methods Eighty-eight elderly patients with depression were selected from March 2014 to March 2016. They were randomly divided into two groups： paroxetine group and escitalopram group, each group of 41 patients The （HAMD） ,Hamilton Anxiety Scale （HAMA） score were evaluated before treatment,and the drug safety was evaluated by the symptom scale （TESS）. The patients were treated with the control group （P 〈 0. 05）. The patients were treated with escitalopram hydrochloride and paroxetine hydrochloride. And then scored at 2 weeks,4 weeks, and 8 weeks after treatment, and the score was compared. Results There were no significant differences in HAMD and HAMA scores between the two groups before treatment （P 〉 0. 05）. After treatment, the scores were significantly decreased in the ladder group, and there was no significant difference between the two groups before and after treatment. After 4 weeks of treatment, the effect of escitalopram was better than that of paroxetine （P 〈 0. 05）. There was no significant difference between the two groups in GDS score （P 〉 0. 05 ）. After treatment for 6 weeks, the effect of escitalopram group was better than that of paroxetine group （ P 〈 0. 05 ）. After treatment, the effect of escitalopram group was better than that of paroxetine group There was no significant difference between the two groups （P 〉 0. 05）. Conclusion Paroxetine and escitalopram in the treatment of senile depression have a significant effect, and escitalopram is more effective and safer.