克拉霉素治疗慢性鼻-鼻窦炎的临床疗效

目的分析使用克拉霉素治疗慢性鼻-鼻窦炎的临床效果。方法将慢性鼻-鼻窦炎患者72例纳入研究。其中伴有鼻息肉25例，将患者设为A组。不伴鼻息肉47例，将患者设为B组。将克拉霉素250mg／d给予患者口服3个月，分析疗效。结果A组和B组经治疗后Lund--Mackey评分均降低（P〈O．05）。服药3个月后，B组的Lund—Mackey评分比A组低（P〈0．05）。经服用克拉霉素3个月后，B组有效率比A组高（97．9％比84．0%，P〈0．05）。两组服用克担霉素3个月后，复查肝肾功能，无明显变化。结论克拉霉素治疗不伴息肉慢性鼻-鼻寞炎的效果更好，且无明显肝肾功能损害，安全性好。

Objective, To analyze the clinical effect of clarithromycin in the treatment of chronic rhinosinusitis. Methods From 2015,6-- 2016,6 choose 72 patients with chronic rhi- nosinuaitia were included in the study. Including 25 patients with nasal polyps, the patients were set to A group. Without nasal polyps in 47 cases, the patients were set to B group. Cla- rithromycin 250rng/d given to patients with oral 3 months.analysis of the efficacy. Results： The Lund--Mackay scores of group A and B were decreased after treatment （P〈 0.05）. The Lund--Mackey score of group B was lower than that of group A （P〈0.05）. After taking clarithromycin for 3 months, the effective rate in group t3 was higher than that in group A （97.9% vs 84,0 % ,P〈0. 05）. Two groups of patients taking clarithromycin 3 months after review of liver and kidney function, no significant changes.Conclusion： clarithromycin treatment of oolyps without chronic rhinosinusitis is better, and no sitnificant liver and kidney function Damage. good security.