噻托溴铵喷雾剂不同给药方式对哮喘合并慢性阻塞性肺疾病患者的影响

目的探讨噻托溴铵喷雾剂不同给药方式对哮喘合并慢性阻塞性肺疾病（coPD）患者的临床应用价值。方法全组97例哮喘合并COPD患者按照治疗方案的差异性将其分组，即安慰剂（安慰剂治疗）31例与B组（噻托溴铵喷雾剂2．5ug／次吸入，早晚）30例、C组（噻托溴铵喷雾剂5ug／次吸入，每晚）36例，对比三组临床疗效。结果安慰剂组的药效、总有效率、生活质量水平均显著低于B组和C组，P（O．05；而B组和C组以上指标差异性甚微，P〉0．05。结论对哮喘合并COPD患者实施等剂量的5ug不同给药方式吸入的疗效均较高，可显著改善患者的肺部功能。

Objective： to investigate the clinical value of bromide bromide spray in patients with asthma complicated with chronic obstructive pulmonary disease （ COPD ）. Methods〉 97 patients with asthma combined with COPD were grouped according to the difference of treatment, namely, 31 cases of placebo （ placebo ） and group b （ zaowan bromide spray, morn- ing and evening ） 30 cases, group c （ bromide spray 5 ug / das Mal, every night ）, compared three groups. Results： the efficacy, total effective rate and quality of life of Comfort were significantly lower than group b and group c, p〈0.05 There was little difference in group b and group c, p〈0.05. Conclusion： the effect of different doses of 5 ug in patients with asthma cnhalation is higher, which can sinificantlv improve the pulmonary function ofpatients.