哮喘患者MIP—1α等炎症因子在血清中的表达及临床意义

Expression and clinical significance of MIP-1 alpha in serum of asthmatic patients

目的观察哮喘患者血清巨噬细胞炎症蛋白10L（MIP-1α）、炎症因子和肺功能水平，并分析其相关性。方法选取2015年3月至2016年8月接受治疗的80例哮喘患者为观察对象，同时选取80例健康成年人的资料作为对照，观察两组血清MIP-1α、炎症因子、免疫球蛋白和肺功能的差异，分析MIP-1α水平与炎症因子、肺功能和免疫球蛋白的相关性。结果哮喘组患者的MIP-1α、IL-6和TNF—α水平均高于对照组（t=-207．04、-33．209、-55．132，P〈0．01）；哮喘组患者的用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、FEV1／FVC、最大呼气中段流量（MMEF）和呼气峰流速（PEF）水平均低于对照组（t=17．100、39．154、22．791、25．391、19．356，P〈0．01）；哮喘组患者的IgG、IgM水平明显低于对照组（t=9．564、7．528，P〈0．01），IgE水平高于对照组（t=-82．683，P〈0．01）；哮喘患者MIP-1α水平与IL-6、TNF—α、IgE水平呈正相关，与FVC、FEV1、FEV1／FVC、MMEF、PEF、IgG、IgM呈负相关。结论哮喘患者血清MIP-1α水平较高，且与患者的炎症细胞因子和肺功能密切相关，可作为临床监测的重要指标。

Objective To investigate the levels of serum macrophage inflammatory protein-1 （MIP-1α）,inflammatory factors and pulmonary function in patients with asthma, and the correlation between them. Methods Eighty patients with asthma were selected who were treated in our hospital from March 2015 to August 2016, and the data of 80 healthy adults were selected as control. The differences of serum MIP-1α, inflammatory factors, immunoglobulin and lung function were observed in two groups. The correlation between MIP-1α and inflammatory factors, lung function and immunoglobulin were analyzed. Results The levels of MIP-1α,interleukin （IL）-6, and tumor necrosis factor-α （TNF-（x） in patients with asthma were significantly higher than those in control group （ t = - 207. 04, - 33. 209, - 55. 132, P 〈 0. 01 ） ; The levels of forced vital capacity （FVC） ,the forced expiratory volume in one second （ FEV1 ）, FEV1/FVC, maximal mid expiratory flow （MMEF）, and peak expiratory flow （PEF） in the asthma group were significantly lower than those in the control group （t = 17. 100, 39. 154, 22. 791, 25. 391, 19. 356, P 〈 0. 01 ）. The IgG and IgM of asthma group were significantly lower than those of the control group （ t=9. 564, 7. 528, P 〈 0. 01 ）. The IgE level was significantly higher than that of the control group （ t = -82. 683,P 〈0. 01 ）. The level of MIP-1α was positively correlated with the levels of IL-6, TNF-α and IgE,and negatively correlated with FVC, FEV1, FEV1/FVC, MMEF, PEF, IgG and IgM in patients with asthma. Conclusions The level of serum MIP-1α in asthmatic patients is high, and is closely related to the inflammatory cytokines and lung function in patients with asthma.