胰岛移植高分子生物材料支架研究进展

Advances in Polymeric Biomaterial Scaffolds for Islet Transplantation

肝脏可能不是胰岛移植最理想的环境,肝内胰岛移植相关的问题阻碍其广泛应用。体内许多部位都曾被尝试用来作为胰岛移植的替代位点,但到目前为止还没有找到一个最适宜胰岛移植的部位。开发生物工程材料支架用于肝外胰岛移植可能是一种理想的选择。概述近3年胰岛移植高分子生物材料支架的研究现状,包括天然高分子材料支架、人工高分子材料支架、人工-天然复合材料支架、全器官脱细胞支架和3D生物打印支架,最后对其前景进行展望。

The liver may not he an optimal environment for islet transplantation. Problems associated with the hepatic transplantation of islets may preclude the broad application of islet transplantation. Many parts of the body have been tested as alternatives for the intrahepatic transplantation sites. Up to now, none of these sites provided ideal environments for pancreatic islets. Therefore, creating a extrahepatic transplantation site for islets through exploiting biological engineered material scaffolds become a preferred option. In this paper, the research progress on polymeric biomaterial scaffolds for islet transplantation in the last three years were reviewed, including natural polymer scaffolds, synthetic polymer scaffolds, synthetic-natural composite scaffolds, whole organ decellularized scaffolds and three-dimensional bioprinting scaffolds. The prospects was proposed and discussed as well.