摘要
目的:探讨乌司他丁对心脏死亡器官捐献(donation after cardiac death,DCD)肝移植术后早期肝功能的保护作用。方法:选择60例于本院行DCD肝移植患者,随机分为实验组和对照组。实验组于术后第1~5日在常规治疗方案基础上按10 000 U/kg·d^(-1)予乌司他丁注射液分次静脉滴注,监测两组患者术后第1~5日丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBil)及C反应蛋白(CRP)。结果:与对照组比较,实验组术后第4日AST、CRP及术后第5日ALT、AST、CRP水平降低(P<0.05)。结论:DCD肝移植术后应用乌司他丁可以抑制术后早期炎症反应,促进术后早期移植肝功能的恢复。
Objective：To investigate protective effect of ulinastatin on early liver function after donation after cardiac death（DCD） liver transplantation.Methods Sixty patients were randomly divided into two groups（experimental group and control group,n=30 each group）.In the experimental group,the patients received ulinastatin（10 000 U/kg·day-（-1））.The plasma levels of ALT,AST,TBil,ALP,GGT,and CRP were measured on 1st-5th days after operation.Results：The plasma levels of AST,CRP on the 4th days and levels of ALT、AST、CRP on the 5th days after operation were remarkably lower in experimental group than those in the control group（P〈0.05）.Conclusions：It is suggested that ulinastatin can inhibit early inflammatory response after operation and promote the recovery of liver function after DCD liver transplantation.
出处
《天津药学》
2017年第4期39-42,共4页
Tianjin Pharmacy
关键词
乌司他丁
肝移植
DCD
肝功能
ulinastatin
liver transplantation
DCD
liver function
