大肠癌患者术后生存率现状及其cox影响因素分析

Analysis of Postoperative Survival Rate and Cox Influencing Factors of Colorectal Cancer Patients

目的:探讨大肠癌患者术后生存率现状及其预后影响因素分析。方法:收集1995~2014年某三甲医院具有完整资料的大肠癌患者1037例,对资料进行生存分析和cox影响因素分析。结果:一共纳入患者1037例,其中男性603例,占58.1%;女性434例,占41.9%;患者平均年龄为58岁;大肠癌患者切除术后1年生存率为91.2%,5年生存率为63.5%,10年生存率为54.2%,20年生存率为44.9%;大肠癌患者BMI越大,患者生存率越高;对于Dukes’分期,B期发生死亡的风险是A期的2.34倍,C发生死亡的风险是A期的3.78倍,D期发生死亡的风险是A期的15.03倍;直肠癌死亡风险是结肠的1.27倍;有慢性便秘史的患者发生死亡的风险是没有的1.26倍;术后无化疗的患者发生死亡的风险是有的2.59倍。结论:本研究的生存率结果与国外研究类似,研究显示,BMI、Dukes’分期、化疗、家族肿瘤史、慢性便秘史、肠梗阻都是患者术后重要的预后影响因素。

Objective：To explore the status of postoperative survival rate and prognostic factors of colorectal cancer patients.Methods：1037cases of colorectal cancer patients with complete data from a hospital in1995～2004were collected,and survival rate and cox influencing factors were analyzed.Results：This study included 1037 patients,including 603 males,accounting for 58.1%;434cases of female,accounting for41.9%;the average age of patients was 58years;1year survival rate of colorectal cancer patients after resection was 91.2%.5-years survival rate was 63.5%,10-years survival rate was 54.2%,20-years survival rate was 44.9%;the greater of BMI of colorectal cancer patients was,the higher survival rate was;for Dukes＇ staging,risk of death of stage B is 2.34 times of A,the risk of death of stage C is 3.78 times of stage A,and the risk of death of stage D is 15.03 times of stage A;the risk of death of rectal cancer is 1.27 times of colon;the risk of death in patients with chronic constipation is 1.26 times of the patients with no constipation;risk of death of patients with postoperative chemotherapy is 2.59 times of the patients without postoperative chemotherapy.Conclusion：The survival rate of this study is similar to that of foreign studies.Studies have shown that BMI,Dukes＇ staging,chemotherapy,family history,chronic constipation,and intestinal obstruction are important prognostic factors in patients.