喹硫平应用于强迫症治疗中的临床疗效分析

Clinical Analysis of Quetiapine in the Treatment of Obsessive-compulsive Disorder

目的:观察喹硫平治疗强迫症的临床疗效及用药安全性。方法:将某院2014年1月~2015年6月收治的62例强迫症患者随机均分对照组与观察组,对照组给予舍曲林结合常规心理干预治疗,观察组在对照组的基础上联合应用喹硫平进行治疗,均以8周为1疗程,1疗程治疗结束后评估两组疗效并进行对比分析,同时观察治疗过程中的不良反应发生率。结果:观察组总有效率为93.55%,显效率为70.97%;对照组总有效率为74.19%,显效率为35.48%;观察组临床疗效显著优于对照组,P<0.01。两组均未见出现严重用药不良反应,观察组患者中困倦、心动过速的发生率显著低于对照组,P<0.01。结论:喹硫平应用于强迫症的治疗中疗效明确,安全可靠,建议推广应用。

Objective：To observe the clinical efficacy and safety of quetiapine in the treatment of obsessive-compulsive disorder.Methods：Sixty-two patients with obsessive-compulsive disorder were enrolled in this study from January 2014 to June 2015.The control group was treated with sertraline combined with routine psychological intervention.The observation group was treated with quetiapine based on the treatment for the control group.It took 8weeks for a course of treatment.Then assess the efficacy of the two groups after treatment,while observing the incidence of adverse reactions during treatment.Results：The total effective rate was 93.55% and the effective rate was 70.97% in the observation group.The total effective rate was74.19% and 35.48%in the control group.There was no serious adverse reaction of the two groups.The incidence of sleepy state and too fast heart-beating in the observation group was significantly lower than those of the control group（P〈0.01）.Conclusion：Quetiapine is effective in the treatment of obsessive-compulsive disorder.It is safe and reliable.It is recommended to promote the application.