无创双水平压力触发在早产儿呼吸窘迫综合征的应用及效果评价

Application of Biphasic tr in Respiratory Distress Syndrome of Newborn and its Efficacy Evaluation

目的探讨无创双水平双向压力触发(Biphasic tr)在早产儿呼吸窘迫综合征的应用及效果。方法回顾性分析汕头市潮阳区大峰医院NICU收治的58例新生儿呼吸窘迫综合征(respiratory distress syndrome of newborn,RDSN)临床资料,将双水平压力触发通气治疗作为观察组,将经鼻持续气道正压通气(NCPAP)通气治疗作为对照组,比较两组RDSN患儿气管插管-肺表面活性物质-拔管(intubation-surfactant-extubation,In Sur E)治疗失败率、机械通气治疗比例、机械通气时间、无创通气时间、常规氧疗时间及并发症情况。结果两组患儿的In Sur E治疗失败率比较差异无统计学意义(P>0.05);In Sur E治疗失败后观察组机械通气治疗比例显著低于对照组,差异有统计学意义(P<0.05);观察组患儿的无创通气时间显著高于对照组,差异有统计学意义(P<0.05);观察组患儿的机械通气时间及常规氧疗时间显著低于对照组,差异有统计学意义(P<0.05);观察组患儿的早产儿视网膜病变及支气管发育不良率显著低于对照组,差异有统计学意义(P<0.05)。结论 Biphasic tr与NCPAP在RDSN患儿的应用可降低机械通气的使用,缩短机械通气时间,降低RDSN患儿视网膜病变及支气管发育不良的风险,值得临床应用。

Objective To explore the application and efficacy of Biphasic tr in respiratory distress syndrome of newborn.Methods 58 cases of respiratory distress syndrome of newborn were retrospectively analyzed. Nasal continuous positive airway pressure（ NCPAP） was used as the control group. Biphasic tr in respiratory distress syndrome was used as the observation group.The mechanical ventilation,mechanical ventilation time,non-invasive ventilation time,conventional oxygen therapy time and complication were compared between the two groups. Results There was no significant difference in the failure rate of In Sur E between the two groups（ P〉0. 05）. The ratio of the mechanical ventilation treatment in the observation group was significantly lower than that in the control group（ P〈0. 05）; the non-invasive mechanical ventilation time,the duration of mechanical ventilation and oxygen therapy in the observation group were significantly lower than those in the control group（ P〈0. 05）. The retinopathy of prematurity and bronchial dysplasia in the observation group were significantly lower than those in the control group（ P〈0. 05）. Conclusion The use of Biphasic tr and NCPAP in children with RDSN can reduce the use of mechanical ventilation,shorten the duration of mechanical ventilation,and reduce the risk of retinopathy and bronchial dysplasia in children with RDSN. It is worthy of clinical application.