肾小球肾炎合并急性间质性肾炎患者采用肾康注射液联合用药治疗的效果观察

Observation of effect by Shenkang injection in drug combination treatment of glomerulonephritis complicated with acute interstitial nephritis patients

目的观察肾小球肾炎合并急性间质性肾炎患者采用肾康注射液联合用药治疗的效果。方法 140例肾小球肾炎合并急性间质性肾炎患者,根据不同治疗方法分为对照组和观察组,各70例。对照组实施常规治疗,观察组在对照组治疗基础上联合肾康注射液、泼尼松、冬虫夏草等药物治疗。比较两组治疗的效果。结果两组患者治疗前血清肌酐、尿素氮、24 h尿蛋白含量水平比较差异无统计学意义(P>0.05);两组治疗后血清肌酐、尿素氮、24 h尿蛋白含量水平均优于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05)。观察组住院时间为(15.69±1.62)d,对照组住院时间为(22.63±1.45)d,观察组住院时间短于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率为97.14%,高于对照组的84.29%,差异具有统计学意义(P<0.05)。结论给予肾小球肾炎合并急性间质性肾炎患者肾康注射液联合用药治疗,能够有效改善患者肾功能,可进一步推广应用。

Objective To observe effect by Shenkang injection in drug combination treatment of glomerulonephritis complicated with acute interstitial nephritis patients. Methods A total of 140 glomerulonephritis complicated with acute interstitial nephritis patients were divided by different treatment measures into control group and observation group, with 70 case in each group. The control group received conventional therapy, and the observation group received additional drug combination by Shenkang injection, prednisone, and cordyceps sinensis to treatment in the control group. Curative effects were compared between the two groups. Results There was no statistically significant difference of serum creatinine, urea nitrogen, and 24 h urine protein content levels before treatment between the two groups （P〉0.05）. Both groups had better serum creatinine, urea nitrogen, and 24 h urine protein content levels after treatment than those before treatment, and the observation group also had better levels than the control group. Their difference had statistical significance （P〈0.05）. The observation group had hospital stay time as＇（15.69 ± 1.62） d, which was （22.63 ±1.45） d in the control group. The observation group had shorter hospital stay time than the control group, and the difference had statistical significance （P〈0.05）. The observation group had higher total effective rate in treatment as 97.14% than 84.29% in the control group, and their difference had statistical significance （P〈0.05）. Conclusion Implement of Shenkang injection in drug combination treatment of glomerulonephritis complicated with acute interstitial nephritis patients can effectively improve their renal function, and this method is worth further promotion and application.