类风湿性关节炎活动期中医证型与免疫学指标相关性

Correlation Study between TCM Syndrome Types and Laboratory Indexes in Active Stage of Rheumatoid Arthritis

目的:探讨类风湿性关节炎患者活动期中医证型与免疫学指标的相关性,为类风湿性关节炎的中医证型客观化研究提供参考与思路。方法:严格按照纳入标准,选取类风湿性关节炎患者303例,记录患者入院时一般资料及免疫学指标,通过统计学方法分析活动期类风湿性关节炎各证型与免疫学指标是否存在相关性。结果:寒湿痹阻证在临床中最为多见;6组中医证候与患者年龄之间无显著相关性(P=0.331>0.05),但是各证候在不同病程的患者中存在显著差异(P=0.005<0.01);血沉、C-反应蛋白、类风湿因子、抗角蛋白抗体、抗环瓜氨酸多肽抗体等免疫学指标在各中医证型中比较,差异无统计学意义(P>0.05)。结论:血沉、C-反应蛋白、D-二聚体、纤维蛋白原、血小板在类风湿性关节炎活动期均有所升高,但各指标在6种中医证候中无显著性差异。在类风湿性关节炎活动期,活血化瘀法应始终贯穿于各证型的治疗过程。

Objective ：To investigate the relationship between TCM syndrome and laboratory index of patients with rheumatoid ar-thritis（RA） in active stage, and to provide reference and ideas for the objective study of TCM syndrome type in rheumatoid arthri-tis. Methods ： In strict accordance with the inclusion criteria, selecting 303 cases of RA patients, recorded the related index of gen-eral information and laboratory, and analyzed whether there is a correlation between types of RA in active stage and laboratory in-dex by statistical method. Results：Cold dampness obstruction syndrome was the most common in clinical;no correlation relation-ship between 6 groups of TCM syndromes and age of patients （P =0.331 〉0.05） ,but there was differences between the varioussyndromes in different disease patients （ P = 0. 005 〈 0.01 ） ; compared ESR, C-reactive protein, rheumatoid factor, anti keratin anti-body, the positive rate of anti cyclic citrullinated peptide antibody in TCM syndrome types showed that the difference was not statis-tically significant （ P 〉 0.05 ） Conclusion ： ESR, C-reactive protein, two D-dimer, fibrinogen, platelet significantly increase in activeRA patients, but the indexes in the 6 kinds of TCM syndrome have no significant difference; in the active stage of rheumatoid ar-thritis, treatment of Huoxuehuayu therapy throughout each type.Reference citafion：Gujienaitehan Baikelimu, Bayan Aikehaiti, WEI Rong. Correlation Study between TCM Syndrome Types andLaboratory Indexes in Active Stage of Rheumatoid Arthritis [ J]. Acta Chinese Medicine,2017,32 （8） ：1551 -1554.