非酒精性脂肪肝及其ALT水平与高血压的相关性

Study on the correlation of nonalcoholic fatty liver disease and its ALT levels with hypertension

目的:研究非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)及其谷丙转氨酶(alanine aminotransferase,ALT)水平与高血压的相关性。方法:选取2015年1月至2016年12月治疗的NAFLD者500例作为研究对象,同期体检中心健康者100例为对照组。按照疾病进展情况分为病程不变组(ALT≤40 U/L)160例、病程改善组(40 U/L<ALT≤80 U/L)170例和病程加重组(ALT>80 U/L)170例。比较四组患者间与高血压相关的多项指标;分析ALT与高血压的相关性。结果:NAFLD患者高血压患病率高于对照组(P<0.05),随着ALT升高,高血压患病率和颈动脉内膜中层厚度(intima-media wall thickness,IMT)依次增加(P<0.05);ALT水平与血压呈正相关(r=0.367、0.348,P<0.05)。结论:NAFLD可能与高血压的发病有一定的相关性,ALT升高可能对高血压的形成有促进作用。

Objective： To study the correlation of nonalcoholic fatty liver disease（ NAFLD） and its ALT levels with hypertension. Methods：500 patients with NAFLD hospitalized from January 2015 to December 2016 were chosen as the research objects and 100 healthy subjects as the control group. According to the progress of the disease,they were divided into the mild disease group（ 160 cases）（ ALT≤40 U/L）,the improved group（ 170 cases）（ 40 U/L ALT≤ 80U/L） and the hyperactivity group（ 170 cases）（ ALT〉 80 U/L）. A number of indicators associated with hypertension were compared in the four groups and the correlation of ALT and hypertension was analyzed. Results： The incidence rate of hypertension in the patients with NAFLD was higher than that in the control group（ P〈0. 05）,and with the increasing of ALT,the incidence rate of hypertension and intima-media wall thickness（ IMT） increased（ P〈0. 05）. There was a positive correlation between ALT levels and blood pressure（ r = 0. 367,0. 348,P〈0. 05）. Conclusion： NAFLD may have a certain correlation with the incidence of hypertension and elevated ALT can also promote the formation of hypertension.