中药复方真武冲剂对慢性心力衰竭患者中医证候及MCP-1、BNP的影响

Effect of Compound Zhenwu Granule on TCM Syndrome in Patients with Chronic Heart Failure and Influence of MCP-1 and BNP

目的:探究复方真武冲剂对慢性心力衰竭患者中医证候、MCP-1和BNP的影响。方法:选取我院CHF患者(NYHAⅡ~Ⅳ级)40例,随机分为两组,对照组20例根据西医常规治疗充血性心力衰竭的治疗原则,采用一般慢性充血性心力衰竭的常规治疗;治疗组20例,在对照组的治疗基础上加服复方真武冲剂。两组疗程均为4周。治疗结束后,比较两组患者中医证候积分、MCP-1和BNP的差异。结果:两组中医证候疗效比较,治疗组总有效率为90.0%,对照组的总有效率为65.0%,两组比较差异显著(P<0.05);两组治疗后血MCP-1水平均有所降低(P<0.05),但治疗组较对照组下降水平更为明显(P<0.05);两组治疗后血BNP水平均有所降低(P<0.05),但治疗组较对照组下降水平更为明显(P<0.05)。结论:复方真武冲剂可温阳益气、活血利水,具有提高冠脉血流量、加强心肌收缩、提升心率、扩大心脏搏出量的作用,对CHF患者中医证候、神经内分泌过度激活以及炎症过程均有一定的干预作用。

Objective ： To explore the the effect of Compound Zhenwu Granule on TCM syndrome in patients with chronic heart failure, the influence of the MCP-1 and BNP. Methods ： Selected our hospital patients with CHF （ NYHA Ⅱ- Ⅳ）,40 cases were randomly divided into two groups, control group 20 cases according to the principle of conventional Western medicine treatment of congestive heart failure, using regular routine therapy of chronic congestive heart failure ; The treatment of treatment group 20 cases, in the control group on the basis of given Compound Zhenwu Granule. Two groups of a course of 4 weeks. After the treatment, compared two groups of patients with TCM syndrome integral, the difference of MCP-1 and BNP. Results ： Two groups of curative effect comparison of syndromes, the treatment group total effective rate was 90.0%, control group total effective rate was 65.0%, two groups are significant difference （ P〈0.05 ）; The two groups after treatment the blood level of MCP-1 were reduced （ P〈0.05 ）, but the treatment group than the control group decreased more significantly （ P〈0.05 ）; Two groups of blood BNP levels were reduced after treatment （ P〈0.05 ）, but the treatment group was decreased more significantly than the control group （P〈0.05）. Conclusion： Compound Zhenwu Granule can warming Yang and supplementing Qi, invigorating the circulation of the water, increasing coronary blood flow, enhancing myocardial contraction, improving heart rate, expanding the role of the cardiac stroke volume, TCM syndrome in patients with CHF, neuroendocrine excessive activation and inflammatory process have a certain intervention effect.