肠道菌群在多囊卵巢综合征病理生理过程中作用与研究

Role and Study of Intestinal Flora in Pathophysiological Process of Polycystic Ovary Syndrome

多囊卵巢综合征是育龄期妇女常见的一种内分泌代谢紊乱性疾病,主要特征为稀发排卵或不排卵、高雄激素血症、胰岛素抵抗和(或)高胰岛素血症,是导致育龄期女性不孕症的主要原因之一,其发病机制至今仍不完全清楚。肠道菌群是人体不可或缺的"微生物器官",对维持人体健康至关重要。近年来研究提示,肠道菌群失调以及弱炎症反应成为肥胖、高脂血症以及2型糖尿病等代谢性疾病的重大影响因素之一。该文旨在探讨肠道菌群在多囊卵巢综合征病理生理过程中的作用与研究,以期为多囊卵巢综合征的治疗提供新的帮助。

Polycystic ovary syndrome is a common endocrine and metabolic disorders in women of childbearing age, its main features are sporadic ovulation or no ovulation, hyperandrogenism, insulin resistance and/ or hyperinsulinemia, is one of the leading causes of infertility in women of childbearing age, its pathogenesis is still not fully clear. Human intestinal flora is indispensable ＂microbial organ＂, it is essential for the maintenance of human health. Recent studies suggest that intestinal flora and weak inflammatory are one of the major factors responsing to obesity, hyperlipidemia, type 2 diabetes and other metabolic diseases. This article aims to explore the role and study the of intestinal flora in the pathophysiologieal process of polycystic ovary syndrome, in order to provide new help for the treatment of polyeystic ovary syndrome.