原发性高血压病患者动态动脉硬化指数与肾实质剪切波速度的相关性研究

Correlative study on ambulatory arterial stiffness index and shear wave velocity of renal parenchyma in patients with primary hypertension

目的探讨原发性高血压病患者动态动脉硬化指数(AASI)与肾实质剪切波速度(SWV)的相关性。方法选取75例原发性高血压病患者(高血压组)和60例健康体检者(对照组),通过24 h动态血压监测分析血压参数特点,计算AASI;应用声触诊组织定量分析技术测量两组肾皮质、髓质SWV,分析AASI与肾皮质、髓质SWV及肾功能实验室指标的相关性。结果高血压组和对照组AASI值分别为0.59±0.18和0.40±0.13,两组比较差异有统计学意义(P<0.01);高血压组肾皮质与髓质SWV均明显高于对照组[(2.34±0.86)m/s vs.(1.81±0.56)m/s;(1.97±0.84)m/s vs.(1.68±0.58)m/s],差异均有统计学意义(均P<0.05)。AASI与肾皮质和髓质SWV均呈正相关(r=0.325、0.268,均P<0.05),AASI与尿素氮、肌酐均呈负相关(r=-0.325、-0.387,均P<0.01)。结论原发性高血压病患者AASI与肾实质SWV和肾功能有一定关系,可以反映其肾脏损害程度。

Objective To evaluate the correlation between ambulatory arterial stiffness index（AASI） and shear wave velocity（SWV） of renal parenchyma in patients with primary hypertension . Methods Seventy-five patients with primary hypertension（primary hypertension group） and 60 healthy subjects（healthy control group） were selected . 24 h ambulatory blood pressure monitoring was performed and the blood pressure parameters were analyzed,then AASI was calculated. The shear wave velocity of renal cortex and medulla were measured by virtual touch tissue quantification.The correlation between AASI and SWV,blood urea nitrogen（BUN）,creatinine（Cr） were analyzed.Results AASI in primary hypertension group was higher than that in healthy control group（0.59±0.18 vs. 0.40±0.13,P〈0.01）.The SWV of renal cortex and medulla in primary hypertension group were higher than that in healthy control group [（2.34 ±0.86）m/s vs.（1.81 ±0.56）m/s,（1.97 ±0.84）m/s vs.（1.68 ±0.58）m/s, both P〈0.05].AASI was positively correlated with the SWV of renal cortex and medulla（r=0.325,0.268,both P〈0.05）.AASI was negatively correlated with BUN and Cr （r=-0.325,-0.387,both P〈0.01）.Conclusion AASI is closely related to the SWV of renal parenchyma,and it can reflect the renal damage in patients with primary hypertension.