瞬时波强技术联合超声评价2型糖尿病患者桡动脉弹性及结构异常

Assessment of radial artery wall elasticity and structure in patients with type 2 diabetes mellitus by wave intensity combined with ultrasonography

目的探讨瞬时波强技术联合超声评价2型糖尿病患者桡动脉弹性及结构的临床应用价值。方法选取84例2型糖尿病患者并按根据病程分为两组,A组(病程≤10年)42例,B组(病程>10年)42例,另选取42例健康志愿者为正常对照组。应用瞬时波强技术分别检测各组桡动脉弹性,同时应用超声测量其双侧桡动脉内-中膜厚度(r IMT),并将获取的数据进行统计学分析。结果 A、B组的血管顺应性(AC)、瞬时加速度波强(W1)及瞬时减速度波强(W2)均低于正常对照组;B组AC、W1及W2均低于A组,差异均有统计学意义(均P<0.05)。A、B组血管压力应变弹性(Eρ)、血管硬化参数(β)及脉搏波传导速度(PWVβ)均高于正常对照组,B组Eρ、β及PWVβ高于A组,差异均有统计学意义(均P<0.05)。三组负向波面积比较,差异均无统计学意义。A、B组r IMT均大于正常对照组,B组r IMT大于A组,差异均有统计学意义(均P<0.05)。结论应用瞬时波强技术联合超声可客观、无创地评价2型糖尿病桡动脉弹性及结构的异常,具有一定的临床价值。

Objective To explore the clinical value of wave intensity（WI） combined with ultrasonography in evaluation of radial artery wall elasticity and structure in patients with type 2 diabetes mellitus（T2DM）.Methods A total of 84 patients with T2DM were enrolled and divided into two groups：group A（42 cases,the course≤10 years） and group B（42 cases,the course〉10 years）.And 42 healthy subjects were enrolled as control group.WI was used to measure the elasticity parameters of radial artery in all the groups,and ultrasonography was used to measure the intima medial thickness of both sides of the radial artery（rIMT）.The results were analyzed.Results The arterial compliance（AC）,accelerating wave intensity（W1） and decelerating wave intensity （W2） in group A and B were significantly lower than those in control group（all P〈0 . 05）. AC , W1 and W2 in group B were significantly lower than those in group A（all P〈0 . 05）. The vascular pressure strain elastic modulus（Eρ）, vascular sclerosis parameters（β） and pulse-wave velocity（PWVβ） in group A and B were significantly higher than those in control group（all P〈0 . 05）. Eρ,β and PWVβ in group B were significantly higher than those in group A（all P〈0 . 05）. There was no statistical difference of the negative wave area among three groups.The rIMT in group A and B were significantly higher than that in control group（P〈0.05） and the rIMT in group B was higher than that in group A（P〈0.05）.Conclusion WI combined with ultrasound can evaluate the elasticity and the structure of radial artery in T2DM patients objectively and non-invasively,it has important clinical value.