血必净注射液对PNS“微炎症”hs-CRP、IL-6水平的影响

Influence of Xuebijing injection on hs-CRP and IL-6 level of PNS “micro-inflammation”

目的:观察血必净注射液对原发性综合征(PNS)"微炎症"患者血清超敏C-反应蛋白(hs-CRP)、白芥素-6(IL-6)水平含量的影响。方法:选45例PNS患者,随机分为对照组22和观察组各23例。对照组给予常规对症治疗,治疗组在对照组基础上给予血必净注射液静滴,10天为1疗程。比较治疗前后两组患者临床证候疗效及血清hs-CRP、IL-6含量水平的变化。结果:对照组总有效率为63.63%,治疗组为91.30%(P<0.01)。与治疗前比较,两组患者治疗后血清hs-CRP、IL-6含量水平较治疗前显著降低(P<0.01);与对照组治疗后比较,治疗组治疗后血清hs-CRP、IL-6水平明显降低(P<0.05)。结论:血必净注射液能有效改善PNS患者"微炎症"状态。

Objective： to observe the influence of Xuebijing injection on content level of high sensitive C-reactive protein（ hs-CRP） and interleukin-6（ IL-6） in serum of patients with primary nephrotic syndrome（ PNS） ＂ micro-inflammation＂. Methods： 45 cases of patients,who were selected and diagnosed as PNS,were divided into control group（ 22 cases） and treatment group（ 23 cases） randomly. The control group was treatedconventionally,while the treatment group was treated with intravenous drip of Xuebijing injection on the basis of control group,10 days as a course of treatment. The curative effect of clinical syndrome and the change of hs-CRP and IL-6 content level in serum were compared before and after treatment between two groups of patients. Results： The total effective rate of control group was 63. 63%,while that of treatment group was 91. 30%; compared between two groups,there was significant difference（ P〈0. 01）. Compared with before treatment,the level of hs-CRP and IL-6 content in serum of patients after treatment in two groups was significantly lower than that before treatment（ P〈0. 01）. Compared with control group after treatment,the level of hs-CRP and IL-6 content in serum after treatment in treatment group was significantly lowered（ P〈0. 05）. Conclusion： Xuebijing injection can effectively improve the ＂ microinflammation＂ state of patients with PNS.