从生物学诱导到工程化组装--组织工程心肌血管化的研究现状及展望

From biological induction to engineering assembly——the current status and perspective on vascularization of engineered heart tissue

工程化心肌补片(engineered heart tissues,EHTs)目前已成为心肌修复、再生的希望所在,但如何能实现移植物的快速血管化却一直是影响其走入临床的"瓶颈"问题之一。本文将综合探讨近几年EHTs血管化策略的进展,以期为最终克服移植物血供限制,推动EHTs走入临床探索出一条新路。

The engineered heart tissues （EHTs） is regarded as a hope for myocardial repair and regeneration. But a series of ＂bottleneck＂ problems, such as vascularization, hinder their clinical translation. This review focuses on the strategies to vascularization of EHTs and encourages the emergence of novel EHTs that can meet clinic requirement properly.