基于数据挖掘和分析石菖蒲的潜在功能分析

Data Mining and Analysis on Potential Functions of Acori Tatarinowii Rhizoma Based on Ancient Prescriptions

目的:利用《普济方》数据库管理系统,结合文献考证和现代药理学研究与临床应用,挖掘和分析石菖蒲潜在功能,扩大临床应用范围。方法:分析《普济方》数据库管理系统含石菖蒲复方所治病证的分布和构成,同时考察历代本草记载的石菖蒲功用,并与2015年版《中国药典》相比较,发现古今功用主治的不同,挖掘和分析石菖蒲的潜在功能,结合现代药理学和临床应用加以佐证。结果:在《普济方》数据库中检索含石菖蒲复方758首,所治病证317个,分为30类,根据病证提炼功能,其中开窍醒神、明耳目、止痢、止痉、温胃化湿功能与2015年版《中国药典》记载内容相吻合,但治疗中风、诸痹、咳喘、疼痛,疥癣、癥瘕积聚、痈疮等病证的功能未被收录。结合现代药理学研究和临床应用验证石菖蒲具有平肝息风、祛风散寒除湿、止咳平喘、杀虫止痒、软坚散结、解毒消痈功能。结论:通过数据分析、文献考证及现代药理学研究与临床应用的佐证,确认石菖蒲具有平肝息风、祛风散寒除湿、止咳平喘、杀虫止痒、软坚散结、解毒消痈的潜在功能。此外,石菖蒲止痛功能还有待于进一步的现代药理学研究加以验证。

Objective： To mine and analyze potential function of Aeori Tatarinowii Rhizoma using the Pujifang database management system, literatures and modern pharmacology studies and clinical application, in order to expand the scope of clinical application. Method： The Pujifang database management system was used to retrieve the distribution and compositions of ancient compounds containing Acori Tatarinowii Rhizoma, and study the overall functions. Meanwhile, the functions of Acori Tatarinowii Rhizoma recorded in old herbalism documents were investigated by comprehensive summary. The results were further compared with Chinese Pharmacopeia to find the similarities and differences of its ancient and present functions, and explore its potential functions. This could be verified by modern pharmacological study and clinical application. Result： In the Pujifang database, 758 ancient compounds containing Acori Tatarinowii Rhizoma were retrieved and used to treat 317 symptoms, which were divided into 30 categories. According to the disease-based functions, the functions of inducing resuscitation,improving eyesight and hearing, stopping dysentery, antispasmodic, warming stomach and resolving dampness were consistent with the records in Chinese Pharmacopeia. However, the functions of treating stroke, arthralgia, cough and asthma, ache, itch, concretions and gatherings, sore carbuncle were not recorded. Modern pharmacological studies and clinical application showed that Acori Tatarinowii Rhizoma can suppress hyperactive liver for calming endogenous wind, expel cold and remove dampness, control cough and asthma, kill parasites to relieve itch, soften hardness to dissipate stagnation, and remove toxicity for eliminating carbuncles. Conclusion： Through data analysis, literature research and modern pharmacology studies and clinical application, Acori Tatarinowii Rhizoma is proved to suppress hyperactive liver for calming endogenous wind, expel cold and remove dampness, relieve cough and asthma, kill parasites to relieve itch, soften hardness to dissipate stagnation, and remove toxicity for eliminating carbuncles. However, its function of relieving pain shall be further verified by modern pharmacological studies.