200例HIV/AIDS病人心电图改变与CD4^+T淋巴细胞计数的关系

Changes of electrocardiogram in 200 patients with HIV/AIDS and the relationship with CD4^+ T lymphocytes

目的分析艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)心电图改变与CD4^+T淋巴细胞(简称CD4细胞)计数的关系,以及HIV/AIDS病人心电图有无特征性改变。方法根据CD4细胞计数结果分级(I级:>500个/μL;Ⅱ级200个/μL至≤500个/μL;Ⅲ级≤200个/μL),比较三组HIV/AIDS病人心电图异常率的差异和各组心电图特征性改变的差异。结果心电图异常率,CD4细胞计数I级为25.0%,Ⅱ级60.5%,Ⅲ级76.7%,三组之间差异有统计学意义(χ~2=16.51,P<0.01)。心电图的特征性改变按频率从高到低依次为快心律失常、ST-T改变、左房室肥大、慢心律失常、低电压、右房室肥大。不同CD4细胞计数组别的异常心电图比较,快心律失常的差异有统计学意义(χ~2=7.01,P<0.05)。结论 HIV/AIDS病人心电图异常率、快心律失常均与CD4细胞计数分级有关。

Objective To explore the relationship between the electrocardiogram changes and the classification of CD4-＋T lymphocytes and to analyze the characteristic changes of electrocardiogram（ECG）in human immunodeficiency virus（HIV）/acquired immunodeficiency syndrome（AIDS）patients.Methods CD4-＋T lymphocyte cell（CD4cell）counts were classified into three groups（Class I：CD4〉500/μL;Class II：200/μLCD4e≤500/μL;Class III：CD4 ≤200/μL）and the abnormal rate of ECG was compared to analyze the characteristic changes of ECG in the three groups.Results The abnormal rate of ECG for class I was 25%,for class II 60.5%,and for class III76.7%,with the difference statistically significant between the three groups（χ-2=16.51,P〈0.01）.The characteristic changes of ECG were from high to low in the sequence of fast arrhythmia,ST-T changes,left atrial ventricular hypertrophy,slow arrhythmia,low voltage,and right atrial ventricular hypertrophy.Among them,fast arrhythmia was the factor of statistically significant difference between the three groups（χ^2=7.01,P〈0.05）.ConclusionThe abnormal rate of ECG in HIV/AIDS patients is related to the CD4 grading,as well as the fast arrhythmia.