生蒲黄汤联合西医治疗眼底出血疗效分析

Curative Effect of Using Shengpuhuang Decoction Combined with Western Medicine in the Treatment of Fundus Hemorrhage

目的:观察生浦黄汤联合西医治疗眼底出血的疗效。方法:将2014.07~2016.07本院50例眼底出血患者(87眼)采用密封信封法按1:1随机分组,25例(42眼)接受氨甲苯酸、维生素C和原发病对症治疗者归为对照组,另25例(45眼)接受在上述治疗基础上配合生浦黄汤治疗者归为联合组,比较两组疗效。结果:联合组患眼眼底出血治疗总有效率95.56%,视力改善总有效率88.89%,对照组分别为80.95%和71.43%,两组差异具有统计学意义(P<0.05);治疗后,两组中医症候积分均显著降低,D-二聚体(D-D)、白介素-6(IL-6)水平显著降低,且联合组降低幅度大于对照组,差异具有统计学意义(P<0.05);两组治疗期间均未见明显不良反应。结论:生浦黄汤联合西医治疗可明显改善患者眼底出血症状,提升患者视力,改善患者纤溶状态和炎症反应,安全有效,值得推荐。

Objective： To analyze the curative effect of Shengpuhuang Decoction combined with western medicine in the treatment of fudus hemorrhage. Methods 50 cases of patients with fundus hemorrhage（ 87 eyes） treated in the hospital from July 2014 to July 2016 were equally divided into two groups by the sealed envelope method. 25 cases（ 42 eyes） treated with conventional PAMBA,vitamin C and the treatment of primary diseases were included into the controlled group,and the other 25 cases（45 eyes） additionally treated with Shengpuhuang Decoction were included into the combined group. The curative effect was compared between the two groups. Results The total effective rate of treatment for fudus hemorrhage and total effective rate of improvement of visual acuity in the combined group were 95. 56% and 88. 89%,respectively while those in the controlled group were 80. 95% and 71. 43%,respectively（ P〈0. 05）. After treatment,the TCM symptom scores,levels of D-dimer（ D-D）,interleukin-6（ IL-6） in the two groups were significantly decreased,the changes were more significant in the combined group than that in the controlled group（ P〈0. 05）. There was no obvious adverse reaction in the two groups during treatment. Conclusion： Shengpuhuang Decoction combined with western medicine can significantly relieve the symptoms of fundus hemorrhage,improve visual acuity,improve fibrinolytic status,inflammatory reactions and endothelial function,safe and effective.