中医辨证论治联合西药治疗抗磷脂综合征复发性流产临床研究

Clinical Study of Applying Syndrome by Traditional Chinese Medicine Combined with Western Medicine in the Treatment of Patients with Recurrent Spontaneous Abortion Of Antiphospholipid

目的:观察中西医结合治疗抗磷脂综合征复发性流产的临床疗效及探讨其作用机制。方法:选取2015年1~12月来本院就诊的复发性流产患者,诊为磷脂综合征者87例,从确定妊娠开始,随机分为2组,对照组43例,观察组44例。对照组以阿司匹林(50mg,口服,1日1次)、强的松(10mg,1日1次)、依诺肝素(4000U,皮下注射,1日1次)、羟氯喹(0.2g,按下注射,1日1次),进行治疗,观察组在对照组的基础上进行中医辨证施治,两组患者均治疗至妊娠结束。比较两组患者抗磷脂抗体转阴率及妊娠结局。结果:治疗后观察组抗体转阴率显著高于较对照组(P<0.05),观察组妊娠结局及新生儿出生情况也明显优于对照组(P<0.05)。结论:中西医结合治疗抗磷脂综合征复发性流产具有良好的临床疗效,值得临床推广。

Objective： To investigate clinical efficacy and mechanism of combining traditional Chinese and western medicine in the treatment of recurrent spontaneous abortion with antiphospholipid syndrome. Methods： 87 cases of recurrent spontaneous abortion patients in the hospital with recurrent abortion were randomly divided into 2 groups,the controlled group of 43 cases,the observation group of 44 cases. The controlled group was treated with aspirin（ 50 mg/1 times/day） ＋ prednisone（ 100 mg/1 times/day） and hydroxychloroquine（ 0. 2 g/1 times/day） ＋ subcutaneous enoxaparin（ 4000 u/ih） treatment,the observation group received traditional Chinese medicine treatment on the basis of the controlled group. Two groups of patients were treated until the end of the pregnancy,and then compared two groups of patients with antiphospholipid antibody negative rate and pregnancy outcome. Results： After treatment,the observation group antibody negative rate was significantly higher than that of the controlled group（ P〈0. 05）,the outcome of pregnancy and birth was significantly better than the controlled group（ P〈0. 05）. Conclusion：It had a good clinical effect on the treatment of recurrent spontaneous abortion with antiphospholipid syndrome for combine traditional Chinese and western medicine,which was worthy of clinical promotion.