Hippo/YAP信号通路与细胞增殖相关信号通路交叉作用的研究进展

Research progress on the crosstalk between Hippo/YAP signaling pathway and cell proliferation-related signaling pathways

Hippo/YAP信号通路首次被发现于果蝇中,在哺乳动物中具有高度保守的特性,可通过直接或间接地调节细胞增殖、程序性细胞死亡以起到平衡机体内环境稳态、维持器官大小的作用。YAP作为Hippo信号通路中的一个转录共激活因子,与磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)、Wnt/β-联蛋白、细胞外信号调节激酶(ERK)1/2等通路中相关分子相互作用,使得Hippo通路与其他增殖调控相关信号通路形成"交通",构成一个复杂的信号通路网,共同调控细胞的增殖。本文就目前对Hippo信号通路中共激活因子YAP与增殖调控信号通路间的交叉影响及其机制的研究进展作一综述。

Hippo/YAP signaling pathway was discovered in Drosophila firstly. It is highly conserved in mammals and can regulate cell proliferation and apoptosis directly or indirectly, which can keep the homeostasis and size of organs in vivo. YAP can act as a transcription coactivator in Hippo signaling pathway with some moleculars in phosphatidylinositol 3-kinase（PI3K）/protein kinase B（AKT）, Wnt/β-catenin and extracellular signal-regulated kinases（ERK） 1/2. Hippo pathway is involved in the complex signaling pathway net, as a crosstalk between Hippo and other proliferation-related signaling pathways exists, which regulates cell proliferation. In this study, we summarize the research progress of the effect and mechanism of this crosstalk between coactivator YAP in Hippo signaling pathway and signaling pathways-controlled proliferation.