Advances in Genetic Engineering Vaccine against Chicken Coccidiosis

鸡球虫基因工程疫苗的研究进展(英文)

Coccidiosis is a protozoan disease that seriously threatens the poultry in-dustry. At present, the prevention and treatment of chicken coccidiosis mainly rely on chemical drugs and coccidia live vaccine. However, drug control has problems of drug resistance and drug residue, and the coccidia live vaccine has drawbacks of pathogenicity, high production costs and virulence enhancement. Instead, genetic en-gineering vaccine is easy to operate, stable, safe and efficient, so it has become a hot spot in the prevention of chicken coccidiosis. In this paper, the research status, immune mechanism, immune effect＇s influencing factors and cytokine adjuvant appli-cation of genetic engineering vaccine against chicken coccidiosis were reviewed to provide some reference for the research and application of chicken coccidiosis gene vaccine.

鸡球虫病是严重危害养禽业的一种原虫病。目前鸡球虫病的防治主要是依靠化学药物和活球虫疫苗,但药物防治存在抗药性和药物残留,球虫活疫苗具有致病性、生产成本高、可能产生"返强"的弊端。而基因工程疫苗则具有易操作、稳定、安全和高效等优点,成为预防鸡球虫病的研究热点。该文主要从鸡球虫基因疫苗的研究现状、免疫机理、免疫效果影响因素、细胞因子佐剂应用等方面进行了综述,以便为鸡球虫基因疫苗的研究与应用提供参考。