新辅助化疗治疗胃癌的效果观察与研究

Observation and Study of Neoadjuvant Chemotherapy in the Treatment of Gastric Cancer

目的:观察与研究新辅助化疗治疗胃癌的临床效果。方法:随机抽取2012年1月-2016年12月本院收治的50例胃癌患者设作试验对象,根据随机数字表法将其分为对照组和观察组,各25例。对照组应用奥沙利铂联合5-氟尿嘧啶、亚叶酸钙治疗,观察组应用替吉奥联合奥沙利铂新辅助化疗方案治疗。比较两组疾病控制情况和不良反应、生活质量变化情况等指标。结果:观察组疾病控制率达88%,对照组疾病控制率达84%,两组控制效果比较,差异无统计学意义(P>0.05);观察组不良反应发生率为8%,低于对照组的32%,差异有统计学意义(P<0.05);观察组生活质量评分明显优于对照组,差异有统计学意义(P<0.05)。结论:新辅助化疗方案治疗胃癌效果较好,可以提高疾病控制率,降低不良反应,明显改善患者的生活质量,提高患者耐受性,值得推广应用。

Objective：To observe and study the therapeutic effect of neoadjuvant chemotherapy in the treatment of gastric cancer.Method：A total of 50 patients with gastric cancer were enrolled in our hospital from January 2012 to December 2016 and were divided into the control group and the observation group according to random number table method,25 cases in each group.The control group was treated with Oxaliplatin plus 5-fluorouracil and leucovorin,the observation group was treated with solid plus oxaliplatin neoadjuvant chemotherapy regimen.Disease control,adverse reactions and quality of life of two groups were compared.Result：The control rate of the observation group was 88%,the control group was 84%,there was no statistical significance in two groups（P〉0.05）.The incidence of adverse reactions of the observation group was 8%,which was significantly lower than 32% in control group,the difference had statistical significance（P〈0.05）.The SF-36 score of the observation group was significantly better than that of the control group,the difference had statistical significance（P〈0.05）.Conclusion：Neoadjuvant chemotherapy regimen is effective in treating gastriccancer,which can improve the control rate of disease and reduce the adverse reaction,improve the quality of life of patients and patient＇s tolerance,it is worthy to be popularized and applied.