肝纤四项含量与Treg细胞在慢性乙型肝炎发展中的作用分析

The Effects of Four Elements of Liver Fibrosis and Treg Cells on the Development of Chronic Hepatitis B

目的探讨肝纤四项含量与Treg细胞在慢性乙型肝炎(CHB)发展中的作用。方法选取2012年5月—2016年12月在我院与无锡五院门诊、住院部接受治疗的151例CHB、肝硬化患者作为本次研究对象,其中CHB患者为103例,肝硬化患者为48例,检测151例CHB、肝硬化患者和115例正常者(对照组)外周血的CD4^+CD25^(high)、CD4^+CD25^(high)CD127^(low)(Treg)细胞。结果与对照组相比肝硬化患者肝纤四项指标差异有统计学意义,P<0.01。CHB患者和肝硬化患者CD4^+CD25^+、CD4^+CD25^(high)127^(low)两种调节性T细胞含量较高。结论血清肝纤四项是检测肝纤维化的重要指标,及时治疗能大辐减少肝硬化乃至肝癌发生。

Objective To investigate the effects of four elements of liver fibrosis and Treg cells on the development of chronic hepatitis B（CHB）. Methods From May 2012 to December 2016 in our hospital and wuxi five outpatient and inpatient treatment of 151 patients with CHB and liver cirrhosis patients as the research object, including 103 cases of CHB patients with liver cirrhosis, 48 cases of patients were detected in 151 cases of CHB patients with cirrhosis, and 115 normal subjects（control group） peripheral blood CD4~＋CD25^（high）, CD4~＋CD25^（high）CD127^（low）（Treg） cells. Results Compared with the control group, the four indexes of liver fibrosis in cirrhosis patients were statistically significant, P〈0.01. CD4~＋CD25~＋ and CD4~＋CD25^（high）127^（low） were the two regulatory T cells in patients with CHB and cirrhosis. Conclusion The four indexes of serum, liver and fiber are important indexes for the detection of hepatic fibrosis. Timely treatment can reduce the occurrence of cirrhosis and even liver cancer.