单唾液酸四己糖神经节苷脂治疗新生儿窒息并发缺氧缺血性脑病的临床效果

Clinical Effect of Monosialoteterahexosyl Ganglioside in the Treatment of Neonatal Asphyxia Complicated With Hypoxic Ischemic Encephalopathy

目的探讨单唾液酸四己糖神经节苷脂治疗新生儿窒息并发缺氧缺血性脑病(HIE)的临床效果。方法抽取本院2016年1月—2017年1月收治的80例窒息并发HIE的新生患儿为研究对象,随机分为对照组与研究组,前组给予胞磷胆碱治疗,后组采用单唾液酸四己糖神经节苷脂治疗,比较两组临床疗效。结果研究组神经症状恢复时间短于对照组,同时治疗后各个时间段的NBNA评分也高于对照组(P<0.05)。结论单唾液酸四己糖神经节苷脂治疗新生儿窒息并发缺氧缺血性脑病效果显著。

Objective To investigate the clinical effect of monosialoteterahexosyl ganglioside in the treatment of neonatal asphyxia complicated with hypoxic ischemic encephalopathy（HIE）. Methods From January 2016 to January 2017, 80 cases of neonatal asphyxia complicated with HIE patients in our hospital were selected as the research object, randomly divided into control group and study group. The control group was treated with citicoline treatment, the study group was treated with monosialoteterahexosyl ganglioside the clinical efficacy was compared between the two groups. Results The recovery time of neurological symptoms in the study group was shorter than that in the control group, and the NBNA scores at each time period after treatment were higher than that in the control group（P〈0.05）. Conclusion The effect of monosialoteterahexosyl ganglioside in the treatment of neonatal asphyxia complicated with hypoxic ischemic encephalopathy is significant.