高渗盐水联合布地奈德、沙丁胺醇对毛细支气管炎患儿肺功能的影响

Effect of hypertonic saline combined with budesonide and salbutamol on lung function in children with capillary bronchitis

目的探讨高渗盐水联合布地奈德、沙丁胺醇对毛细支气管炎患儿肺功能的影响。方法选择2015年9月至2016年9月我院收治的毛细支气管炎患儿96例,随机将其分为对照组与观察组,各48例。两组患者均进行抗感染、抗病毒等常规治疗,对照组采用0.9%氯化钠注射液联合布地奈德、沙丁胺醇治疗,观察组采用雾化吸入3%高渗盐水联合布地奈德、沙丁胺醇治疗,比较两组患儿的治疗效果。结果治疗后,两组患儿达峰容积比(VPTEF/VE)、达峰时间比(tPTEF/tE)、潮气量及呼吸频率(RR)较治疗前均明显改善(P<0.05);治疗后,观察组VPTEF/VE、tPTEF/tE、潮气量高于对照组,呼吸频率(RR)低于对照组(P<0.05);观察组治疗总有效率明显高于对照组(P<0.05)。结论给予毛细支气管炎患儿高渗盐水联合布地奈德、沙丁胺醇治疗效果显著,可改善患儿肺功能,促进患儿康复。

Objective To investigate the effect of hypertonic saline combined with budesonide and salbutamol on lung function in children with capillary bronchitis. Methods From September 2015 to September 2016, 96 cases of children with capillary bronchitis in our hospital were selected and randomly divided into control group and observation group, with 48 cases in each group. All the patients were given conventional treatment with anti-infection and anti-virus, the control group received 0.9% sodium chloride injection combined with budesonide and salbutamol, the observation group accepted aerosol inhalation of 3% hypertonic saline combined with budesonide and salbutamol. The curative effects of the two groups were compared. Results After treatment, the VPTEF/VE, tPTEF/tE, tidal volume and respiratory rate （RR） of the two groups significantly improved than those before treatment （P〈0.05）; after treatment, the PTEF/VE, tPTEF/tE, tidal volume of the observation group were higher than those of the control group, and the RR were lower than that of the control group （P〈0.05）; the total effective rate of the observation group was significantly higher than that of the control group （P〈0.05）. Conclusion Hypertonic saline combined with budesonide and salbutamol in children with capillary bronchitis has significant curative effects, which can improve lung function and recovery of children with capillary bronchitis.