米索前列醇联合缩宫素预防和治疗产后出血的临床效果

Clinical effect of misoprostol combined with oxytocin in the prevention and treatment of postpartum hemorrhage

目的探讨米索前列醇联合缩宫素应用于产后出血的预防与治疗中的临床效果。方法选取2015年4月至2016年2月我院收治的60例产妇为研究对象,随机分为对照组与观察组,各30例。胎儿娩出后,对照组产妇给予缩宫素,观察组产妇在此基础上使用米索前列醇。比较两组产妇产后不良反应及出血情况、血压及出血量。结果两组产妇不良反应发生率比较,差异无统计学意义(P>0.05)。观察组产后出血发生率明显低于对照组(P<0.05)。治疗后,两组产妇舒张压及收缩压均下降(P<0.05),但观察组与对照组产妇舒张压及收缩压比较,差异无统计学意义(P>0.05)。观察组产妇产后2、24h出血量均少于对照组(P<0.05)。结论米索前列醇联合缩宫素应用于产后出血的预防及治疗中,能够有效降低产后出血的发生风险,减少产后出血量,值得临床推广应用。

Objective To investigate the clinical effect of misoprostol combined with oxytocin in the prevention and treatment of postpartum hemorrhage. Methods Sixty cases of maternal admitted in our hospital from April 2015 to February 2016 were selected as the study objects, and they were randomly divided into control group and observation group, with 30 cases in each group. The incidence of adverse reactions and blood loss, blood pressure and blood loss volume of the two groups were compared. Results The incidence of adverse reaction in the two groups had no significant difference （P〉0.05）. The incidence of blood loss of the observation group was lower than that of the control group （P〈0.05）. After treatment, the diastolic blood pressure and systolic blood pressure of the two groups decreased （P〈0.05）, but there was no significant difference in the diastolic blood pressure and systolic blood pressure between the two groups （P〉0.05）. The blood loss volume at 2 and 24 h of the observation group were less than those of the control group （P〈0.05）. Conclusion Misoprostol combined with oxytocin in the prevention and treatment of postpartum hemorrhage can significantly reduce the risk of postpartum hemorrhage, and reduce the blood loss volume, which is worthy of application and popularization in clinic.