神经节苷脂与苯巴比妥治疗新生儿缺血缺氧性脑病临床疗效对比

Clinical effect comparison of ganglioside and phenobarbital on neonatal hypoxic-ischemic encephalopathy

目的分析神经节苷脂与苯巴比妥治疗新生儿缺血缺氧性脑病(HIE)的临床疗效。方法收集我院2011年3月至2016年3月收治的70例HIE患儿,随机分为观察组和对照组,每组35例。在一般治疗基础上,观察组患儿给予单唾液酸四己糖神经节苷脂治疗,对照组患儿给予苯巴比妥治疗,比较两组患儿的治疗效果。结果观察组患儿治疗总有效率为100.00%,高于对照组的71.43%,差异具有统计学意义(P<0.05)。治疗前,两组患儿的NBNA评分比较,无显著差异(P>0.05);治疗后,两组患儿的NBNA评分均升高,且观察组患儿的NBNA评分高于对照组,差异均有统计学意义(P<0.05)。结论单唾液酸四己糖神经节苷脂治疗HIE的临床效果显著,治愈率高,安全、可靠,可有效改善患者的神经细胞受损情况,降低HIE的致残率,此方法可在临床推广使用。

Objective To evaluate the clinical effect of ganglioside and phenobarbital on neonatal hypoxic-ischenfic eneephalopathy （HIE）. Methods A total of 70 cases of HIE children treated in our hospital from March 2011 to March 2016 were randomly divided into observation group and control group, with 35 cases in each group. On the basis of general treatment, the observation group was given monosialoglycans ganglioside treatment, while the control group received phenobarbital treatment. The therapeutic effects of the two groups were compared. Results The total effective rate was 100.00% in the observation group, which was higher than 71.43% in the control group, the difference was statistically significant （P〈0.05）. There was no significant difference in the NBNA score between the two groups before treatment （P〉0.05）; after treatment, the NBNA scores of both groups increased, the NBNA score in the observation group was higher than the control group, the differences were statistically significant （P〈0.05）. Conclusion Monosialoglycans ganglioside is effective and safe in the treatment of HIE, which can effectively improve the damage of nerve ceils in the patient＇s and reduce the disability rate, this method can be widely used in clinical practice.