细毡毛忍冬化学成分研究(Ⅱ)

Study on Chemical Constituents of Lonicera similis(Ⅱ)

目的：对细毡毛忍冬花蕾的化学成分进行研究。方法：综合运用大孔吸附树脂、硅胶柱层析、制备薄层色谱和反相C_（18）柱色谱等多种色谱方法对其进行分离和纯化,运用核磁共振谱、质谱等光谱数据鉴定化合物的结构。结果：从细毡毛忍冬花蕾提取物中分离和鉴定了8个化合物,分别为：medioresinol（Ⅰ）、pinoresinol（Ⅱ）、丁基松柏苷（Ⅲ）、5-（hydroxymethyl）furfural（Ⅳ）、绿原酸丁酯（Ⅴ）、绿原酸甲酯（Ⅵ）、槲皮素（Ⅶ）、绿原酸（Ⅷ）。结论：其中,化合物Ⅰ~Ⅵ为首次从该植物中分离得到,化合物Ⅰ、Ⅲ、Ⅳ为首次从该属植物中分离得到。

Objective：To investigate the chemical constituents from the buds of Lonicera similis. Methods：The compounds were iso- lated and repeatedly purified by macroperous resin, silica gel column, preparation of TLC and Rp C18 chromatography. Their structure were elucidated by chemical properties and spectroscopic analysis. Results：Eight compounds were isolated and identified as mediores- inol （ Ⅰ ）, pinoresinol （ Ⅱ ）, butylconiferin （ Ⅲ）, 5- （ hydroxymethyl ） furfural （ Ⅳ ）, butyl chlorogenate （ Ⅴ ）, methy chlorogenate （ Ⅵ ）, quercetin （ Ⅶ）, chlorogenic acid （ Ⅷ ）. Conclusion ： Compounds Ⅰ-Ⅵ are isolated from this plant for the first time, and compounds Ⅰ , Ⅲ and IVare isolated from Lonicera genus for the first time.