特利加压素治疗80例脓毒血症难治性休克的分析

Clinical efficacy of terlipressin in the treatment of 80 cases of intractable septic shock

目的:探讨特利加压素治疗脓毒血症难治性休克的应用价值。方法:选择80例脓毒血症难治性休克患者,经多巴胺和去甲肾上腺素治疗无效后给予特利加压素治疗,观察记录给予特利加压素6 h、12 h、24 h患者的心率、血压、休克指数和尿量的变化。结果:特利加压素使用后6 h患者的平均动脉压(MAP)明显升高,休克指数显著降低(P<0.05);特利加压素使用后12 h、24 h患者的MAP和尿量明显升高,休克指数和心率显著降低(P<0.05)。结论:脓毒血症难治性休克患者应用特利加压素的临床效果显著。

Objective： To investigate the value of the application of terlipressin in the treatment of intractable septic shock. Methods： Eighty cases of patients with refractory septic shock were selected and treated with terlipressin after dopamine and norepinephrine were invalid. The changes of heart rate and blood pressure, urine volume and shock index were observed and recorded at 6 h, 12 h and 24 h after terlipressin was used. Results： The mean arterial pressure （MAP） was significantly risen while shock index was significantly decreased at 6 h after treatment （P〈0.05）. The MAP and urine volume were obviously risen while shock index and heart rate were decreased at 12 h and 24 h after treatment （P〈0.05）. Conclusion： The clinical effect of terlipressin for the treatment of intractable septic shock in patients is significant.