还原型谷胱甘肽结合复方甘草酸苷治疗酒精性肝硬化的临床效果分析

Effect of reduced glutathione combined with compound glycyrrhizin glucoside in treating alcoholic liver cirrhosis

目的探讨酒精性肝硬化患者采用还原型谷胱甘肽结合复方甘草酸苷治疗的临床效果。方法酒精性肝硬化患者100例随机分为观察组、对照组各50例,对照组使用还原型谷胱甘肽进行治疗,观察组在对照组的治疗基础上加用复方甘草酸苷。观察两组患者临床体征和相应病症改善情况;观察丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转肽酶三项肝功能指标;比较两组患者临床疗效。结果观察组患者恶心、巩膜黄染、腹胀、乏力改善情况优于对照组,丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转肽酶均低于对照组,差异均有统计学意义(P<0.05);观察组患者临床总有效率显著高于对照组(P<0.05)。结论还原型谷胱甘肽结合复方甘草酸苷应用于酒精性肝硬化治疗比单独使用还原型谷胱甘肽,临床效果更加显著,可以明显改善患者临床体征和相关病症,优化肝功能,提高临床疗效。

Objective To determine the clinical effect of reduced glutathione combined with compound glycyrrhizin glucoside in treating alcoholic liver cirrhosis. Method 100 patients with alcoholic liver cirrhosis were randomly divided into an experimental group （n = 50） and a control group （n = 50）. The control group were treated with reduced glutathione while the experimental group were treated with reduced glutathione combined with compound glycyrrhizin glucoside. The clinical signs and symptoms improvement of the two groups were then observed. The alanine aminotransferase, aspartate aminotransferase, gamma GGTP （gamma glutamyl transpeptidase） and three liver function indexes of both groups were also observed. The efficacy of the different treated as given to the two groups were compared. Findings The experimental group were found to improve better than the control group in easing nausea, yellowing sclera, abdominal distension, and fatigue. The alanine aminotransferase, aspartate aminotransferase, and gamma GGTP （gamma glutamyl transpeptidase） of the experimental group were lower than those of the control group. The differences were statistically significant （P 〈 0.05）. The rate of efficacy of treatment in the experimental group was significantly higher than that of the control group （P 〈 0.05）. Conclusion Reduced glutathione combined with compound glycyrrhizin glucoside can serve as an more effective medicine than reduced glutathione alone in treating alcoholic liver cirrhosis. It can improve the clinical symptoms and related disorders and liver function as well.