摘要
急性早幼粒细胞白血病(APL)虽为最易治疗的急性髓系白血病之一,但仍存在一定的早期病死率。作为APL的有效治疗药物,三氧化二砷(As_2O_3)凭借其强大的抗白血病功效,已在世界范围内得到应用。As_2O_3进入人体后,经过复杂的代谢过程会产生一系列代谢产物并发挥功能,但这些代谢产物往往具有较大的毒性,若超过人体负荷即可能产生相应的损害,这可能是As_2O_3治疗白血病过程中产生不良反应的原因。通过调整给药方式间接调节患者体内砷代谢产物水平可有效地减少不良反应的发生。
Acute promyelocytie leukemia（APL） is one of the most treatable acute myeloid leukemia, but there remains early mortality. As an effective therapeutic drug for APL, arsenic trioxide （As2O3 ） with strong anti-leukemia effect, has been applied worldwide. As2O3 taken into the body, after a complex metabolic process,it will produce a series of metabolites and function, but the metabolites may generate greater toxicity. If the body cannot bear the toxicity, there will be damage to the body, which may be the reason of adverse effects during the treatment. By adjusting administration approach of arsenic trioxide, to regulate the level of metabolites in the body,the adverse reactions can be effectively reduced.
出处
《医学综述》
2017年第17期3344-3347,共4页
Medical Recapitulate
基金
黑龙江省自然科学基金(D201128)
高等学校博士学科点专项科研基金(优先发展领域)(20122307130003)
