甲胎蛋白低浓度阳性肝细胞癌的早期诊断

Early Diagnosis of Heptocellular Carcinoma with Low Positive Serum AFP Level

目前甲胎蛋白(AFP)作为肝细胞癌(HCC)的一项诊断标准,其浓度标准有一定的局限性,通过提出低浓度AFP阳性,结合其他诊断方法,提高肝癌的早期诊断率。在存在肝占位性病变(SOL)时,低浓度的AFP(AFP21~200μg/L)也可作为诊断HCC的参考标准,结合临床,发现低浓度AFP作为诊断参考有利于HCC的早期诊断,能有效避免低浓度AFP升高的HCC患者的漏诊,同时低浓度AFP升高结合影像学方法,如B型超声、CT、磁共振成像等进行联合的诊断,提高了单一诊断手段的敏感性和特异性。

As a current diagnostic criteria of hepatocellular carcinoma, the concentration standard of alpha-fetoprotein （AFP） has certain limitations, by offering low positive serum AFP level, combing with other diagnosis methods, the early diagnostic rate of hepatocellular carcinoma can be improved. The AFP level of 21-200 μg/L can be used reference diagnostic criteria of hepatocellular carcinoma when existing space occupying lesion（SOL） ;combining the clinical,low AFP level-would be helpful to the early diagnosis of HCC and avoid missed diagnosis of HCC. Low AFP level combining with imageological examination such as ultrasonography, CT and MRI would have higher sensitivity and specificity than the single diagnostic method.