DRD3基因Ser9Gly多态性与抗精神病药物疗效的Meta分析

Meta-analysis of the association of DRD3 gene Ser9Gly polymorphism with the efficacy of antipsychotics

目的系统评价DRD3基因Ser9Gly多态性与抗精神病药物的疗效,为临床提供循证参考。方法计算机检索Cochrane图书馆、Pub Med、Web of Science、中国知网、万方数据库、维普数据库,收集DRD3基因Ser9Gly突变与抗精神病药物疗效的非随机试验,提取资料并评价质量后,采用STATA 12.0统计软件进行Meta分析。结果共纳入11项,合计1 254例患者。Meta分析结果显示,DRD3基因Ser9Gly突变与抗精神病药物疗效有显著性差异。未见明显发表偏倚。结论 DRD3基因Ser9Gly多态性与抗精神病药物疗效有关。

Objective To systematically review the association of DRD3 gene Ser9Gly polymorphism with the efficacy of antipsychotics,and provide evidence-based reference for clinical treatment.Methods Non-randomized trials about the association of DRD3 gene Ser9Gly polymorphism with the efficacy of antipsychotics were retrieved from Cochrane Library,PubMed,Web of Science,NCBI,Wanfang Database and Weipu Database.Meta-analysis was performed by using STATA software after data extraction and quality evaluation.Results Totally 11 studies were enrolled,involving 1 254 patients.Results of meta-analysis showed that DRD3 gene Ser9Gly polymorphism was significantly associated with the efficacy of antipsychotics.Conclusion DRD3 gene Ser9Gly polymorphism has correlation with the effects of antipsychotics.