化疗对肺癌患者血清总胆固醇及甘油三酯水平的影响

Effects of Chemotherapy on Total Cholesterol andTriglyceride Levels in Patients with Lung Cancer

目的 探究肺癌患者化疗前后血清甘油三酯（TG）和总胆固醇（TC）水平变化.方法 以2013年6月-2015年9月我院门诊收治的126例肺癌患者为观察组,同时随机选取80例入院进行健康检查,结果正常者为对照组.观察组入院时、化疗疗程结束后空腹清晨抽取静脉血,对照组入院次日取血,提取血清并对TG、TC水平进行检测.以对照组结果为标准,观察肺癌患者TG、TC水平化疗前后变化情况,同时比较不同病理分型肺癌患者TG、TC水平.结果 观察组患者TC水平明显低于对照组（P〈0.05）,两组TG水平比较差异无统计学意义（P〉0.05）;患者化疗后TC水平上升（P〈0.05）,TG水平无明显改变（P〉0.05）;鳞癌患者TC水平较其他分型患者低（P〈0.05）,甘油三酯水平组间比较差异无统计学意义（P〉0.05）.结论 肺癌患者血清TC水平较正常者低,化疗后TC水平明显上升.患者血清TC水平检测可作为疾病发展、预后评估的一项指标.

Objective To explore changes of total cholesterol （TC）and triglyceride （TG）levels in patients with lung cancer before and after chemotherapy. Methods 126 patients with lung cancer treated in our hospital from Jun. 2013 to Sep. 2015 were selected as observation group. 80 healthy people were selected as control group. Fasting venous blood was drew for patients in observation group upon admission to hospital and after chemotherapy. Fasting venous blood was drew for patients in control group on the next day. Serum was extracted, TG and TC levels were detected. Changes of TG and TC levels were observed in patients with lung cancer based on the final results of patients in con- trol group. TG and TC levels were compared among different pathological types in patients with lung cancer. Results The TC level in observation group was significantly lower than that in control group（P 〈 0.05）. There was no signifi- cant difference on TG level between the two groups（ P 〉 0.05 ）. The TC level was increased after chemotherapy （P 〈 0.05 ）. There was no significant difference on TG level after chemotherapy（ P 〉 0.05 ）. The TC level in squamous car- cinoma was lower than that in the other types of lung cancer（ P 〉 0.05 ）. There was no significant difference on TG level among groups （P 〉 0.05 ）. Conclusion The TC level in patients with lung cancer is lower than that in healthy control. The TC level is greatly increased after chemotherapy. The serum TC level can be considered as an index for disease development and prognosis evaluation.