摘要
目的 :探讨联用腹腔镜手术与促性腺激素释放激素激动剂(GnRH-a)治疗深部浸润型子宫内膜异位症的临床效果。方法 :将中江县人民医院收治的52例深部浸润型子宫内膜异位症患者随机分为实验组和对照组。对两组患者进行腹腔镜手术治疗,为实验组患者在术后应用GnRH-a进行治疗,不为对照组患者应用此药。在术后对两组患者进行1年的随访,观察其临床疗效、病情复发及自然妊娠的情况,并评估其发生疼痛的情况。结果 :与对照组患者相比,实验组患者治疗的总有效率较高,差异有统计学意义(P<0.01)。与对照组患者相比,在术后1年实验组患者病情的复发率较低,差异有统计学意义(P<0.05)。在术后1年,两组患者性交痛的发生率相比较差异无统计学意义(P>0.05)。与对照组患者相比,实验组患者在术后1年其痛经及慢性盆腔痛的发生率较低,差异有统计学意义(P<0.05)。两组患者在术后1年的自然妊娠率相比较,差异无统计学意义(χ~2=0.04,P=0.849)。结论 :采用腹腔镜手术联合GnRH-a治疗深部浸润型子宫内膜异位症能取得理想的效果,可有效缓解患者慢性盆腔痛及痛经的症状,降低其病情的复发率。
Objective：To investigate efficacy of laparoscopic surgery combined with gonadotropin-releasing hormone agonist（GnRH-a） for treatment of deep invasive endometriosis.Methods： Select Fifty-two patients with deep invasive endometriosis treated in People＇s Hospital of Zhongjiang county were randomly divided into experimental group and control group,the patients in the two groups were treated with laparoscopic surgery,after surgery,apply GnRH-a on experimental group, but not apply on the control group.After 1 year from surgery,we follow-up 2 groups of patients then observe curative efficacy,reccurence rate, natural pregnancy situation of 2 groups,and assess irritation occurs of 2 groups. Results：Compare with control group,total effective rate of experimental group is higher（P〈0.05）. Recurrence of experimental group is lower than control group after 1 year from surgery（P〈0.05）. After 1 year from surgery, occurrence of dyspareunia in 2 group have no statistical significant（P〈0.05）.Compare with control group,occurrence of dysmenorrhea and pelvic inflammatory disease of experimental group is lower after 1 year from surgery（P〉0.05）. After 1 year from surgery, natural pregnancy of 2 groups has no statistical significant（χ^2=0.04,P=0.849）. Conclusion： Efficacy of laparoscopic surgery combined with gonadotropin-releasing hormone agonist（Gn RH-a） for treatment of deep invasive endometriosis is good,apply this therapy on the patients of deep invasive endometriosis can relieve pain and decrease recurrence of disease.
