摘要
目的 :探讨用大剂量的盐酸氨溴索治疗急性肺损伤的临床效果。方法 :将四川省自贡市富顺县晨光医院在2015年4月至2016年4月期间收治的112例急性肺损伤患者分为常规剂量组和大剂量组,每组各有56例患者。用常规剂量的盐酸氨溴索对常规剂量组患者进行治疗。用大剂量的盐酸氨溴索对大剂量组患者进行治疗。治疗结束后,观察对比治疗前后两组患者的动脉血氧分压(Pa O2)及动脉血氧分压与吸入气氧浓度的比值(Pa O2/Fi O2),同时比较其治疗的总有效率及肺不张、肺部感染等并发症的发生率。结果 :大剂量组患者治疗的总有效率明显高于常规剂量组患者,其Pa O2的水平及Pa O2/Fi O2的值均明显高于常规剂量组患者,其肺不张及肺部感染等并发症的发生率均明显低于常规剂量组患者,差异具有统计学意义(P<0.05)。结论 :用大剂量的盐酸氨溴索对急性肺损伤患者进行治疗可显著提高其治疗的效果,改善其血气指标,降低其肺不张及肺部感染等并发症的发生率。
Objective： To explore the clinical effect of ambroxol hydrochloride for treatment of acute lung injury.Methods： 112 patients with acute lung injury treated in Chenguang Hospital of Fushun county from April 2015 to April 2016 were randomly divided into control group and experimental group,56 patients each group. Treat control group with routine dose of ambroxol hydrochloride,treat experimental group with high dose of ambroxol hydrochloride. After treatment, compare PaO2 and ratio of PaO2 to FiO2 of 2 groups. And compare total effective rate and in incidence of compliance of 2 groups. Results： PaO2 level, ratio of PaO2 to FiO2 and total effective rate of experimental group are significant higher than control group, and incidence of compliance is lower than control group（P〈0.05）.Conclusion： Apply high dose of ambroxol hydrochloride for treatment of patients with acute lung injury can improve effective rate of treatment and blood gas indexes, decrease incidence of compliance.
