苦参碱联合胃复春片对慢性萎缩性胃炎癌前病变患者胃酸分泌功能的影响

Effect of matrine combined with Weifuchen tablets on gastric acid secretion in patients with chronic atrophic gastritis

目的探讨苦参碱联合胃复春片对慢性萎缩性胃炎(chronic atrophic gastritis,CAG)癌前病变患者胃酸分泌功能的影响.方法入选浙江省永康医院消化内科160例CAG癌前病变患者,其中80例予胃复春片治疗为对照组,另80例予胃复春片联合苦参碱治疗为研究组.比较2组治疗前后的胃液检测、病理积分、胃镜检查等结果及临床综合疗效.结果治疗后,2组胃液pH值、游离酸、胆汁酸、胃蛋白酶值均明显改善(P<0.05),研究组pH值、游离酸、胃蛋白酶值改善优于对照组(P<0.05);2组萎缩、肠上皮化生、异型增生积分均明显降低(P<0.05),研究组萎缩、肠上皮化生积分明显低于对照组(P<0.05);研究组胃镜下能观察到的溃疡、充血水肿、糜烂、糜烂、出血斑的比例明显低于对照组(P<0.05);研究组总有效率明显高于对照组(93.8%vs 86.2%,P<0.05).结论苦参碱联合胃复春片治疗CAG癌前病变可有效逆转癌前病变,提高疗效,恢复胃酸分泌功能.

AIM To explore the influence of matrine combined with Weifuchun tablets on gastric acid secretion in patients with chronic atrophic gastritis（CAG）.METHODS One hundred and sixty patients with CAG were included and equally divided into either a control group or a study group. The control group was treated with Weifuchun alone, and the study group was treated with Weifuchun tablets combined with matrine. The gastric juice, pathological score, gastroscopic findings before and after treatment, and clinical efficacy between the two groups were compared.RESULTS After treatment, pH value, free acid, bile acid, and pepsin were significantly improved in both groups（P〈0.05）, and the improvement was significantly better in the study group than in the control group（P〈0.05）. The atrophy, intestinal metaplasia, and dysplasia scores were significantly reduced in both groups（P〈0.05）, and these scores were significantly lower in the study group than in the control group（P〈0.05）. The proportion of patients with ulcer, congestion, edema, erosion, erosion, or bleeding as revealed by gastroscopy was significantly lower in the study group than in the control group（P〈0.05）. The total effective rate was significantly higher in the study group than in the control group（93.8% vs 86.2%, P〈0.05）.CONCLUSION Matrine combined with Weifuchun tablets can effectively reverse the precancerous lesions, improve curative effect, and restore gastric acid secretion in patients with CAG.