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小剂量螺内酯在老年难治性高血压患者中的疗效及安全性分析 被引量:20

Efficacy and Safety of Low-dose Spironolactone in Elderly Patients With Refractory Hypertension
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摘要 目的:评价小剂量螺内酯在老年难治性高血压患者中的有效性及安全性。方法:选取2015年5月至2015年12月于我院心内科门诊就诊的RH患者85例,其中男性45例,女性40例,年龄72.12±6.34岁。随机分为实验组及对照组。两组在A+C+D治疗方案的基础上,实验组加用螺内酯20mg/d,对照组服用安慰剂。随访8周,观察患者血压、血钾、血肌酐等指标的变化。结果:实验组因出现2例不良反应,及1例失访,共3例退出试验,对照组1例失访;随访8周后两组患者之间的各项指标进行统计学分析,收缩压、舒张压较前明显下降,差异具有统计学意义P<0.05;钾离子、血肌酐有所增高差异具有统计学意义P<0.05;但尚未超过正常参考值的最高限度。结论:老年难治性高血压患者中在A+C+D治疗方案的基础上,加用小剂量螺内酯可有效降低收缩压及舒张压,且耐受性较好。 Objective: To evaluate the efficacy and safety of low-dose spironolactone in elderly patients with refractory hypertension. Methods: In the hospital,85 patients with RH were enrolled from May 2015 to December 2015,including 45 males and 40 females,aged 72.12 ± 6.34 years. They were randomly divided into test group and control group. On the basis of A + C + D regimen,the patients in the experimental group were treated with spironolactone 20mg/day,the control group was given placebo. Followed up for 8 weeks to observe the changes in blood pressure,serum potassium and serum creatinine. Results: In the experimental group,there were 2 cases of adverse reactions,1 case of lost visit,a total of 3 cases of withdrawal test,the control group 1 case lost. The mean value of systolic blood pressure and diastolic blood pressure decreased significantly after 8 weeks follow-up. The difference was statistically significant( P〈0.05); Potassium ion,serum creatinine increased significantly was statistically significant P〈0.05; but not yet exceeded the normal reference value of the maximum. Conclusion: In elderly patients with refractory hypertension in the A + C + D treatment program based on the addition of low-dose spironolactone can effectively reduce systolic and diastolic blood pressure,and tolerance is better.
作者 卢旭 余蕾蕾 陈光辉 LU Xu et al(Department of Cardiology, Chinese PLA General Hospital, Beijing 100011, China)
出处 《河北医学》 CAS 2017年第8期1294-1301,共8页 Hebei Medicine
关键词 难治性高血压 老年 螺内酯 小剂量 Resistant hypertension Elderly Spironolactone Low-dose
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