男性2型糖尿病患者血尿酸与性激素相关性研究

Study on the Relationship between Blood Uric Acid and Sex Hormones in Male Patients with Type 2 Diabetes Mellitus

目的:观察男性2型糖尿病患者血清性激素水平的变化情况,分析血清性激素水平与血尿酸水平之间的关系。方法:选择我院2014年2月至2016年1月收治的男性2型糖尿病患者100例为观察组,选择同期于我院健康体检的男性110例为对照组,比较两组血清性激素水平,观察组不同血尿酸水平患者一般指标、糖代谢指标及性激素水平。结果:观察组血清总睾酮水平低于对照组,而雌二醇、SHBG水平高于对照组,差异有统计学意义(P<0.05);与血尿酸水平159~251μmo L/L组比较,血尿酸水平385~688μmo L/L组FINS、PINS水平升高,总睾酮、SHBG水平明显降低,差异均有统计学意义(P<0.05),年龄、BMI、其他糖代谢及性激素指标差异无统计学意义(P>0.05),其他组间年龄、BMI、各糖代谢及性激素指标比较差异无统计学意义(P>0.05)。结论:男性2型糖尿病患者体内常存在睾酮、E2、SHBG等性激素分泌紊乱,且低血浆SHBG水平与高血尿酸水平显著相关。

Objective： To observe the changes of blood sex hormone levels in male patients with type 2diabetes,and to analyze the relationship between blood sex hormone levels and blood uric acid levels. Methods： 100 cases of male patients with type 2 diabetes in our hospital from February 2014 to January 2016 were selected as observation group,110 healthy males in our hospital were selected as control group,and the levels of blood sex hormones were compared between the two groups,the general indexes,glucose metabolism indexes and sex hormone levels in observation group of patients with different levels of serum uric acid were compared. Results： The total serum testosterone level in the observation group was lower than that in the control group,while the levels of estradiol and SHBG in the observation group were higher than those in the control group,and the difference was statistically significant（ P〈0.05）; Compared with blood uric acid level in 159-251 mol/l group,the levels of FINS and PINS in blood uric acid level in 385-688 mol/l group were significantly increased,and the levels of total testosterone and SHBG were significantly lower,and the difference was statistically significant（ P〈0.05）. There was no significant difference in age,BMI,other glucose metabolism and sex hormones（ P〉0.05）. And there were no significant differences in age,BMI,glucose metabolism and sex hormones between the other groups（ P〉0.05）. Conclusion： In male patients with type 2 diabetes mellitus,there is a disorder of sex hormones such as testosterone,E2,SHBG,and low plasma SHBG levels are significantly correlated with the level of serum uric acid.