葛根芩连汤联合硫辛酸治疗老年糖尿病周围神经病变临床疗效评价

Clinical Effect Evaluation of Gegen Qinlian Decoction Combined with Lipoic Acid on Treatment of Senile Diabetic Peripheral Neuropathy(DPN)

目的:旨在评价葛根芩连汤联合α-硫辛酸治疗糖尿病周围神经性病变(DPN)的临床疗效和安全性。方法:DPN患者90例,随机分为常规组和治疗组,每组各45例,常规组给予0.9%氯化钠注射液200 m L(5m L 10%氯化钾+5 m L 25%硫酸镁+40 mg三磷酸腺苷+100U辅酶A+维生素B1 150 mg+维生素B12 0.5mg),另补加α-硫辛酸注射液600 mg+生理盐水200 m L静脉滴注,1次/d,进行两个疗程,每个疗程持续15 d,期间间隔停药3 d。治疗组在此基础上加用葛根芩连汤,疗程同常规组。观察各组患者的临床症状、体征、评价治疗前后治疗有效率,神经传导速度以及不良反应等。结果:治疗组总体有效率为95.56%,明显优于常规组66.67%,且神经传导速度明显提高,差异均有显著学意义(P<0.05),两组均无不良反应发生。结论:硫辛酸治疗治疗糖尿病周围神经性病变疗效显著,值得临床推广。

Objective： To evaluate the clinical efficacy and safety of Gegen Qinlian Decoction combined with α-lipoic acid in the treatment of diabetic peripheral neuropathy（ DPN）. Methods： Ninety patients with DPN were randomly divided into conventional group and treatment group,45 cases in each group. The conventional group received 0. 9% sodium chloride injection 200 m L（ 5 m L 10% chlorine ＋ Potassium sulfate ＋ 5 m L 25% magnesium sulfate ＋ 40 mg adenosine triphosphate ＋ 100 U coenzyme A ＋ vitamin B1150 mg ＋ vitamin B120. 5 mg）,additionally add α-lipoic acid injection 600 mg ＋ saline 200 m L intravenous infusion for two courses. Each course of treatment lasted 15 days,3 d as the interval. The treatment group on this basis,added Gegen Qinlian Decoction,except to the conventional treatment group.The clinical symptoms and signs of each group were observed. The effective rate,nerve conduction velocity and adverse reaction were evaluated before and after treatment. Results： The total effective rate of treatment group was 95. 56% and significantly higher than the normal group＇s（ 66. 67%）. The nerve conduction velocity of treatment group was also improved obviously. All of then had the significant meaning of difference（ P〈0. 05）. But two groups had no adverse reaction occurred. Conclusion： The therapeutic effect of lipoic acid for the treatment of diabetic peripheral neuropathy was obvious and worthy of clinical promotion.