江苏省健康体检者幽门螺杆菌感染状况分析

Applysis of Helicobacter pylori infection in natural population of Jiangsu Province

目的探讨和了解江苏省健康体检中人群幽门螺杆菌(helicobacter pylori,Hp)的感染情况和分布特征,为进一步防治Hp感染提供参考。方法以2015年1至10月期间,在南京金域医学检验所进行Hp抗体检测的9076名健康体检者为研究对象,以性别、年龄、地区进行分组,应用Hp Ig G抗体检测试剂盒检测其Hp的感染状况,并对各组阳性率进行比对和相关性分析。结果 9076名健康体检者中Hp总感染阳性率为50.71%,其中苏南、苏中、苏北地区的感染阳性率分别为51.27%(3675/7168)、46.75%(108/231)、48.84%(819/1677),各地区组感染阳性率差异均无统计学意义(χ~2=1.87,3.22,0.35;P>0.05);男性和女性Hp感染阳性率分别为52.01%(2403/4620)、49.35%(2199/4456),男性感染阳性率高于女性(χ~2=6.00,P<0.05);Hp感染阳性率在少年、青年、中年、老年组分别为30.23%(13/43)、48.89%(2575/5267)、53.87%(1732/3215)、51.18%(282/551),中老年组的感染阳性率高于青少年组(χ~2=8.04,P<0.05);在同一年龄段的男性和女性组间的Hp感染阳性率差异均无统计学意义(χ2=0.19,3.08,1.83,0.13;P>0.05)。结论江苏省健康体检者中Hp感染阳性率较高,Hp感染与年龄和性别存在相关性,与地区无相关性。中老年及男性高发,应针对不同人群感染情况的分布特征,加强Hp感染的早期防治,提高胃癌早期防治效果。

Objective To investigate the infection and distribution of Helicobacter pylori （Hp） in natural population of Jiangsu Province, and to provide reference for further prevention and treatment of Hp infection. Methods Nine thousand and seventy-six individuals from a physical examination population in Nanjing KingMed Clinical Laboratory Co., Ltd during January 2005 and October 2015 were in this study. These individuals were grouped by sex, age and region. Hp IgG antibody was utilized to detect Hp infection in these individuals. Positive rate of Hp and correlation were analyzed within these groups. Results the overall Hp positive rate in 19 different regions was 50.71%. Positive rates of Hp in individuals from southern Jiangsu, middle Jiangsu and northern Jiangsu population were 51.27% （3675/7168）, 46.75% （108/231） and 48.84% （819/1677） respectively. No significantly different positive rate （Х^2=1.87, 3.22, 0.35; P〉0.05） was found within the three groups. The positive rates of Hp infection in men and women were 52.01% （2403/4620） and 49.35% （2199/4456）. Male infection rate was higher than female （Х^2= 6.00, P〈0.05）. Hp infection rates were 30.23% （13/43）, 48.89% （2575/5267）, 53.87% （1732/3215）, and 51.18% （282/551） in juvenile group, youth group, middle-aged and elderly group, respectively positive rates were higher in middle-aged and elderly group than in juvenile and youth group （Х^2=8.04, P〈0.05）. There was no significant difference between male and female group of different ages （Х^2=0.19, 3.08, 1.83, 0.13; P〉0.05）. Conclusions The positive rate of Hp infection is higher in health check-up population in Jiangsu province. There are correlations between Hp infection and age and sex. There is no correlation between Hp infection and area. The middle-aged and the old are individuals with high Hp infection incidence given the different distribution patterns of Hp infection. Early prevention and treatment of lip infection should be strengthen in order to improve the early prevention of gastric cancer.