摘要
低氧/缺血是临床上常见的基本病理过程和基本死因,同时也是高原、航天、潜水等极端环境所面临的基本问题。作为细胞内源性保护分子,hamartin能够提高细胞在急性低氧/缺血时的耐受性,具有重要的研究意义。Hamartin在低氧/缺血中的作用已成为研究热点,阐明其在低氧/缺血中的保护作用及其DNA甲基化对低氧/缺血的影响,不仅有利于减轻低氧/缺血的损伤,还可以进一步探讨hamartin及其DNA甲基化在其他病理生理中的作用,为后续的临床研究提供理论指导。本文对hamartin的结构、信号传导机制以及在低氧/缺血中的研究进行综述。
Hypoxia/ischemia is a common clinical pathophysiological process and cause of death,and it is a common problem in extreme conditions such as high altitude,astronautics and diving. Hamartin is a kind of effective endogenous neuroprotectant and could increase cell tolerance to acute hypoxia or ischemia,thus,is of significance to research. The role of hamartin in hypoxia/ischemia has been a research focus of many scientists. Elucidating the related protective effect and its DNA methylation on hypoxia/ischemia can not only reduce injury,but also lay a basic for further studying the role of hamartin and its DNA methylation in other pathophysiological processes and provide theoretical guidance for the following clinical study. In this paper,we review the structure,mechanism and role of hamartin and the effect of its DNA methylation on hypoxia/ischemia.
出处
《中国比较医学杂志》
北大核心
2017年第8期85-88,共4页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(81460283,81660307)
内蒙古自然科学基金(2016MS(LH)0307,2014MS0810)
包头医学院博士基金(BSJJ201621,BSJJ201617)
