高压氧联合药物治疗对高血压脑出血康复期脑血流特征、神经损伤程度及神经细胞因子的影响

Effect of hyperbaric oxygen combined with drug therapy on cerebral blood flow characteristics,nerve injury and nerve cytokines in the convalescence of hypertensive cerebral hemorrhage

目的:探讨高压氧联合药物治疗对高血压脑出血康复期脑血流特征、神经损伤程度及神经细胞因子的影响。方法:收集在本院接受治疗、处于康复期的高血压脑出血患者215例,回顾治疗方案并分为接受常规治疗的对照组109例、接受高压氧辅助治疗的观察组106例,均持续治疗1月。对比两组患者治疗前后神经功能及神经营养状态的差异。结果:治疗前,两组患者的脑血管动力学指标水平,神经损伤指标、氨基酸类神经递质、神经营养因子含量的差异无统计学意义。治疗1月后,两组患者Vmean、Qmean的水平以及血清中GABA、Gly、BDNF、NGF、NTF的含量均高于治疗前,R、Wv的水平以及血清中S100B、GEAP、NSE、Glu、Asp的含量均低于治疗前且观察组患者Vmean、Qmean的水平以及血清中GABA、Gly、BDNF、NGF、NTF的含量均高于对照组,R、Wv的水平以及血清中S100B、GEAP、NSE、Glu、Asp的含量均低于对照组。结论:高压氧辅助治疗可有效减轻高血压脑出血康复期患者的神经损伤,优化神经营养状态。

Objective：To study the effect of hyperbaric oxygen combined with drug therapy on cerebral blood flow characteristics,nerve injury and nerve cytokines in the convalescence of hypertensive cerebral hemorrhage.Methods：A total of 215 patients who were in convalescence of hypertension cerebral hemorrhage and treated in our hospital were collected and divided into the control group（n=109）who received conventional therapy and the observation group（n=106）who received adjuvant hyperbaric oxygen therapy after therapeutic plans were reviewed,and both therapies lasted for 1 month.The differences in nerve function and neurotrophic state were compared between the two groups of patients before and after treatment.Results：Before treatment,there was no significant difference in the levels of cerebral hemodynamic index levels as well as nerve injury index,amino acid neurotransmitter and neurotrophic factor contents between the two groups of patients.After 1 month of treatment,Vmean and Qmean levels as well as serum GABA,Gly,BDNF,NGF and NTF contents of both groups of patients were higher than those before treatment,while R and Wv levels as well as serum S100 B,GEAP,NSE,Glu and Asp contents were lower than those before treatment.Vmean and Qmean levels as well as serum GABA,Gly,BDNF,NGF and NTF contents of observation group were higher than those of control group,while R and Wv levels as well as serum S100 B,GEAP,NSE,Glu and Asp contents of observation group were lower than those of control group.Conclusion：Adjuvant hyperbaric oxygen therapy can effectively reduce the nerve injury and optimize the neurotrophic state of patients in the convalescence of hypertensive cerebral hemorrhage.