曲安奈德对老年白内障术后疗效及炎症因子的影响

Effect of triamcinolone acetonide on the curative effect and inflammatory factors of senile cataract

目的:探究曲安奈德对老年性白内障术后前葡萄膜炎的疗效及其对炎症因子的影响。方法:选取老年性白内障患者102例(102眼),随机平均分为对照组和曲安奈德组,对照组给予常规治疗,曲安奈德组在对照组基础上给予前房注射2mg曲安奈德,比较两组患者最佳矫正视力和炎症因子变化。结果:两组术后1、8、24、28周视力均逐渐提高,且同一时间内曲安奈德组较对照组高(P<0.05);两组炎症因子白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均显著下降(P<0.05),曲安奈德组下降程度大于对照组(P<0.05)。结论:老年白内障患者前房注射曲安奈德对抑制前葡萄膜炎的疗效显著,抗炎效果良好,值得临床推广应用。

Objective：To explore the clinical effect of triamcinolone acetonide on postoperative anterior uveitis in senile cataract and its influence on inflammatory factors. Methods： The subjects of this study were selected from 102 cases （102 eyes） of patients with senile cataract admitted, who were evenly divided into the control group and triamcinolone acetonide group on a random basis. The control group was given conventional treatment, and the triamcinolone acetonide group was administrated with 2rag triamcinolone acetonide injected into the anterior chamber of patients in addition to what＇s applied to the control group. The best corrected visual acuity and change of inflammatory factors were compared between the two groups. Results： Patients from both groups had their eyesight gradually improved 1, 8, 24, 28 weeks after operation, and patients from the triameinolone group had better eyesight than their counterparts in the control group in a corresponding period （P〈 0.05）. Both groups experienced a dip in inflammatory interleukin-1β （IL-1β）, interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） levels （P〈 0.05）, and the decrease in the triamcinolone group was more significant than that in the control group （P〈 0.05）. Conclusion： Injecting triamcinolone acetonide into the anterior chamber of patients with senile cataract can inhibits anterior uveitis with its anti-inflammatory property. It is worth clinical promotion.